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Literature DB >> 8259515

Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.

Abstract

Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.

Entities: Chemical Gene

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Year: 1993 PMID： 8259515 DOI： 10.1126/science.8259515

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

185 in total

Review 1. Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.

Authors: Andy Hudmon; Howard Schulman
Journal: Biochem J Date: 2002-06-15 Impact factor: 3.857

2. Structural basis for endothelial nitric oxide synthase binding to calmodulin.

Authors: Mika Aoyagi; Andrew S Arvai; John A Tainer; Elizabeth D Getzoff
Journal: EMBO J Date: 2003-02-17 Impact factor: 11.598

3. Regulation of c-Rel nuclear localization by binding of Ca2+/calmodulin.

Authors: Asa Antonsson; Kate Hughes; Sofia Edin; Thomas Grundström
Journal: Mol Cell Biol Date: 2003-02 Impact factor: 4.272

4. Fluorescence intensity and lifetime distribution analysis: toward higher accuracy in fluorescence fluctuation spectroscopy.

Authors: Kaupo Palo; Leif Brand; Christian Eggeling; Stefan Jäger; Peet Kask; Karsten Gall
Journal: Biophys J Date: 2002-08 Impact factor: 4.033

5. Backbone dynamics of the 8 kDa dynein light chain dimer reveals molecular basis of the protein's functional diversity.

Authors: Jing-Song Fan; Qiang Zhang; Hidehito Tochio; Mingjie Zhang
Journal: J Biomol NMR Date: 2002-06 Impact factor: 2.835

6. Multiplexed sorting of libraries on libraries: a novel method for empirical protein design by affinity-driven phage enrichment on synthetic peptide arrays.

Authors: Claus Hultschig; Ronald Frank
Journal: Mol Divers Date: 2004 Impact factor: 2.943

Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.

Review 1. Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.

2. Structural basis for endothelial nitric oxide synthase binding to calmodulin.

3. Regulation of c-Rel nuclear localization by binding of Ca2+/calmodulin.

4. Fluorescence intensity and lifetime distribution analysis: toward higher accuracy in fluorescence fluctuation spectroscopy.

5. Backbone dynamics of the 8 kDa dynein light chain dimer reveals molecular basis of the protein's functional diversity.

6. Multiplexed sorting of libraries on libraries: a novel method for empirical protein design by affinity-driven phage enrichment on synthetic peptide arrays.

7. Interpretation of NMR relaxation properties of Pin1, a two-domain protein, based on Brownian dynamic simulations.

Review 8. Ratcheting up protein translocation with anthrax toxin.

9. Acidic/IQ motif regulator of calmodulin.

10. Exploring the origins of binding specificity through the computational redesign of calmodulin.