| Literature DB >> 9667830 |
Abstract
Oligonucleotide in vitro selection provides surprisingly specific aptamers to protein targets. Synthetic chemistries for modifying nucleotides have been developed to enhance aptamer binding affinity. The diversity of nucleosides amenable to either triphosphate synthesis or phosphoramidite activation is now sufficiently broad to rival any oligomeric combinatorial library.Entities:
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Year: 1997 PMID: 9667830 DOI: 10.1016/s1367-5931(97)80103-2
Source DB: PubMed Journal: Curr Opin Chem Biol ISSN: 1367-5931 Impact factor: 8.822