| Literature DB >> 9666162 |
I Phillips1, K F Martin, K S Thompson, D J Heal.
Abstract
The effect of gamma-aminobutyric acid (GABA) was investigated on cortical wedges prepared from male Sprague-Dawley rats. GABA evoked concentration-dependent depolarisations (EC50: 0.8 mM), which were attenuated by up to 60% when bicarbonate-buffered aCSF was replaced with HEPES-buffered aCSF. Responses to 1 mM GABA were attenuated by (-)-bicuculline and picrotoxin and were potentiated by chlordiazepoxide and pentobarbitone. Ionotropic glutamate receptor antagonists had no effect. We conclude that GABA-evoked depolarisations are mediated via GABAA receptors, arising in part from HCO3- efflux from cells. Copyright 1998 Elsevier Science B.V. All rights reserved.Entities:
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Year: 1998 PMID： 9666162 DOI： 10.1016/s0006-8993(98)00479-x
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252