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Literature DB >> 19022626

Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas.

Do-Young Kim¹, Kristina A Fenoglio, John F Kerrigan, Jong M Rho.

Abstract

The role of bicarbonate (HCO(3)(-)) in GABA(A) receptor-mediated depolarization of human hypothalamic hamartoma (HH) neurons was investigated using cellular electrophysiological and calcium imaging techniques. Activation of GABA(A) receptors with muscimol (30 microM) provoked neuronal excitation in over 70% of large (18-22 microM) HH neurons in HCO(3)(-) buffer. Subsequent perfusion of HCO(3)(-)-free HEPES buffer produced partial suppression of muscimol-induced excitation. Additionally, 53% of large HH neurons under HCO(3)(-)-free conditions exhibited reduced intracellular calcium accumulation by muscimol. These results suggest that HCO(3)(-) efflux through GABA(A) receptors on a subpopulation of large HH neurons may contribute to membrane depolarization and subsequent activation of L-type calcium channels.

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 19022626 PMCID： PMC2692870 DOI： 10.1016/j.eplepsyres.2008.09.008

Source DB: PubMed Journal: Epilepsy Res ISSN： 0920-1211 Impact factor: 3.045

14 in total

Review 1. Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones.

Authors: J Bormann; O P Hamill; B Sakmann
Journal: J Physiol Date: 1987-04 Impact factor: 5.182

2. The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones.

Authors: R C Thomas
Journal: J Physiol Date: 1977-12 Impact factor: 5.182

3. Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification.

Authors: Olivier Delalande; Martine Fohlen
Journal: Neurol Med Chir (Tokyo) Date: 2003-02 Impact factor: 1.742

4. Wrong-way chloride transport: is it a treatable cause of some intractable seizures?

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5. NKCC1 transporter facilitates seizures in the developing brain.

Authors: Volodymyr I Dzhala; Delia M Talos; Dan A Sdrulla; Audrey C Brumback; Gregory C Mathews; Timothy A Benke; Eric Delpire; Frances E Jensen; Kevin J Staley
Journal: Nat Med Date: 2005-10-09 Impact factor: 53.440

6. Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.

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Journal: Eur J Med Chem Date: 2008-02-29 Impact factor: 6.514

7. Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells.

Authors: Y Fujiwara-Tsukamoto; Y Isomura; A Nambu; M Takada
Journal: Neuroscience Date: 2003 Impact factor: 3.590

8. On the mechanism of GABA-induced currents in cultured rat cortical neurons.

Authors: R Dallwig; J W Deitmer; K H Backus
Journal: Pflugers Arch Date: 1999-01 Impact factor: 3.657

9. GABA-evoked depolarisations in the rat cortical wedge: involvement of GABAA receptors and HCO3- ions.

Authors: I Phillips; K F Martin; K S Thompson; D J Heal
Journal: Brain Res Date: 1998-07-06 Impact factor: 3.252

10. Hypothalamic hamartomas and ictal laughter: evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging.

Authors: S F Berkovic; F Andermann; D Melanson; R E Ethier; W Feindel; P Gloor
Journal: Ann Neurol Date: 1988-05 Impact factor: 10.422

8 in total

Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas.

Review 1. Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones.

2. The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones.

3. Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification.

4. Wrong-way chloride transport: is it a treatable cause of some intractable seizures?

5. NKCC1 transporter facilitates seizures in the developing brain.

6. Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.

7. Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells.

8. On the mechanism of GABA-induced currents in cultured rat cortical neurons.

9. GABA-evoked depolarisations in the rat cortical wedge: involvement of GABAA receptors and HCO3- ions.

10. Hypothalamic hamartomas and ictal laughter: evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging.

1. Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas.

2. L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue.

3. Physiological Role of ATPase for GABA_A Receptor Resensitization.

Review 4. Mechanisms of intrinsic epileptogenesis in human gelastic seizures with hypothalamic hamartoma.

5. Firing behavior and network activity of single neurons in human epileptic hypothalamic hamartoma.

Review 6. The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington's Disease and Its Comorbidities.

Review 7. Electrophysiology of ionotropic GABA receptors.

8. Gap Junctions Contribute to Ictal/Interictal Genesis in Human Hypothalamic Hamartomas.