| Literature DB >> 9662370 |
S Fleury1, R J de Boer, G P Rizzardi, K C Wolthers, S A Otto, C C Welbon, C Graziosi, C Knabenhans, H Soudeyns, P A Bart, S Gallant, J M Corpataux, M Gillet, P Meylan, P Schnyder, J Y Meuwly, W Spreen, M P Glauser, F Miedema, G Pantaleo.
Abstract
We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late increase in proliferating CD4+ T cells associated with the restoration of CD4+ T-cell counts. These results provide strong support for the idea of limited CD4+ T-cell renewal in the early stage of HIV infection and indicate that after effective suppression of virus replication, the mechanisms of CD4+ T-cell production are still functional in early HIV infection.Entities:
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Year: 1998 PMID： 9662370 DOI： 10.1038/nm0798-794
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440