Literature DB >> 22738931

The role of cytokines in the pathogenesis and treatment of HIV infection.

Marta Catalfamo1, Cecile Le Saout, H Clifford Lane.   

Abstract

HIV immune activation plays an important role in the immunopathogenesis of the disease. The mechanisms driving this immune activation are partially defined and likely are the result of multiple factors. The introduction of combination antiretroviral therapy (cART) has improved the life expectancy of HIV infected individuals, however there is evidence that in the setting of "undetectable" HIV-RNA plasma levels, there is some level of persistent immune activation in these patients. A better understanding of the immune activation pathways should be of value in developing complementary therapies to restore the immune systems of patients with HIV infection. This review discusses the cytokine mediated pathways of immune activation of the CD4 and CD8 T cell pools during HIV infection. Published by Elsevier Ltd.

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Year:  2012        PMID： 22738931      PMCID： PMC3726258          DOI： 10.1016/j.cytogfr.2012.05.007

Source DB:  PubMed          Journal:  Cytokine Growth Factor Rev        ISSN： 1359-6101            Impact factor:   7.638


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Authors:  Cecile Le Saout; Megan A Luckey; Alejandro V Villarino; Mindy Smith; Rebecca B Hasley; Timothy G Myers; Hiromi Imamichi; Jung-Hyun Park; John J O'Shea; H Clifford Lane; Marta Catalfamo
Journal:  JCI Insight       Date:  2017-11-16

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Journal:  Cell Mol Immunol       Date:  2017-09-04       Impact factor: 11.530

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Review 4.  Bioanalytical chemistry of cytokines--a review.

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Authors:  Josué Pérez-Santiago; María J Marquine; Debralee Cookson; Rafael Giraud-Colón; Robert K Heaton; Igor Grant; Ronald J Ellis; Scott L Letendre; Scott N Peterson
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