Literature DB >> 9655193

The effect of hexadecylphosphocholine on the degradation of mitochondrial phospholipids.

O Vagina1, F N Gellerich, R Ulbrich-Hofmann.   

Abstract

Hexadecylphosphocholine (HePC) is known as antitumor agent but the mechanism has not yet been understood. In rat liver mitochondria its effect on phospholipid transformation has been studied by quantitative HPTLC and phosphorus determination. From the results it can be concluded that HePC influences the activities of phospholipase A2, phospholipase C, phospholipase D, and lysophospholipase A. The phospholipid transformation as well as the influence of HePC are affected by exogenous calcium ions. In the presence of calcium HePC has been found to inhibit enzyme activities, whereas in the absence of exogenous calcium ions enzymatic phospholipid transformations are activated or inhibited depending on HePC concentrations.

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Year:  1998        PMID： 9655193     DOI： 10.1023/a:1006826122602

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  23 in total

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Journal:  Biochem Pharmacol       Date:  1993-01-26       Impact factor: 5.858

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Journal:  Eur J Cancer       Date:  1995-11       Impact factor: 9.162

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