Literature DB >> 9654048

Regulation of translation initiation factors by signal transduction.

M Kleijn1, G C Scheper, H O Voorma, A A Thomas.   

Abstract

Regulation of eukaryotic translation initiation is a process that requires collaboration between multiple proteins. The cap-binding factor eukaryotic initiation factor (eIF)4E, its binding protein 4E-BP1, and the guanine-nucleotide-exchange factor eIF2B play important roles in the regulation of the rate of protein synthesis. This review describes the regulation of the activity of these three proteins and the signal-transduction pathways involved therein.

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Year:  1998        PMID： 9654048     DOI： 10.1046/j.1432-1327.1998.2530531.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  50 in total

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