Literature DB >> 9653545

Small-molecule-based strategies for controlling gene expression.

C Denison1, T Kodadek.   

Abstract

A central goal in chemical biology is to gain control over biological pathways using small molecules, and the mRNA-synthesizing machinery is a particular important target. New advances in our understanding of transcriptional regulation suggests strategies to manipulate these pathways using small molecules.

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Year:  1998        PMID: 9653545     DOI: 10.1016/s1074-5521(98)90167-3

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  15 in total

1.  Double duplex invasion by peptide nucleic acid: a general principle for sequence-specific targeting of double-stranded DNA.

Authors:  J Lohse; O Dahl; P E Nielsen
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

Review 2.  Chemical approaches to control gene expression.

Authors:  J M Gottesfeld; J M Turner; P B Dervan
Journal:  Gene Expr       Date:  2000

3.  Chemistry for the analysis of protein-protein interactions: rapid and efficient cross-linking triggered by long wavelength light.

Authors:  D A Fancy; T Kodadek
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-25       Impact factor: 11.205

4.  Minimization of a protein-DNA dimerizer.

Authors:  Ryan L Stafford; Hans-Dieter Arndt; Mary L Brezinski; Aseem Z Ansari; Peter B Dervan
Journal:  J Am Chem Soc       Date:  2007-02-10       Impact factor: 15.419

5.  Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides.

Authors:  Bo Liu; Thomas Kodadek
Journal:  J Med Chem       Date:  2009-08-13       Impact factor: 7.446

6.  A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor.

Authors:  Brook E Heaton; Edward M Kennedy; Rebekah E Dumm; Alfred T Harding; Matthew T Sacco; David Sachs; Nicholas S Heaton
Journal:  Cell Rep       Date:  2017-08-15       Impact factor: 9.423

7.  Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry.

Authors:  Katherine D Bauman; Jie Li; Kazuya Murata; Simone M Mantovani; Samira Dahesh; Victor Nizet; Hanna Luhavaya; Bradley S Moore
Journal:  Cell Chem Biol       Date:  2019-03-07       Impact factor: 8.116

8.  Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.

Authors:  Lori W Lee; Christopher E C Taylor; Jean-Paul Desaulniers; Manchao Zhang; Jonas W Højfeldt; Quintin Pan; Anna K Mapp
Journal:  Bioorg Med Chem Lett       Date:  2009-09-01       Impact factor: 2.823

9.  Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors.

Authors:  Sara J Buhrlage; Caleb A Bates; Steven P Rowe; Aaron R Minter; Brian B Brennan; Chinmay Y Majmudar; David E Wemmer; Hashim Al-Hashimi; Anna K Mapp
Journal:  ACS Chem Biol       Date:  2009-05-15       Impact factor: 5.100

10.  Design and synthesis of a cell-permeable synthetic transcription factor mimic.

Authors:  Xiangshu Xiao; Peng Yu; Hyun-Suk Lim; Devanjan Sikder; Thomas Kodadek
Journal:  J Comb Chem       Date:  2007-05-27
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