Literature DB >> 9653124

The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA.

J C Connelly1, L A Kirkham, D R Leach.   

Abstract

Hairpin structures can inhibit DNA replication and are intermediates in certain recombination reactions. We have shown that the purified SbcCD protein of Escherichia coli cleaves a DNA hairpin. This cleavage does not require the presence of a free (3' or 5') DNA end and generates products with 3'-hydroxyl and 5'-phosphate termini. Electron microscopy of SbcCD has revealed the "head-rod-tail" structure predicted for the SMC (structural maintenance of chromosomes) family of proteins, of which SbcC is a member. This work provides evidence consistent with the proposal that SbcCD cleaves hairpin structures that halt the progress of the replication fork, allowing homologous recombination to restore DNA replication.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9653124      PMCID： PMC20913          DOI： 10.1073/pnas.95.14.7969

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  70 in total

Review 1.  When replication forks stop.

Authors:  H Bierne; B Michel
Journal:  Mol Microbiol       Date:  1994-07       Impact factor: 3.501

2.  Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein.

Authors:  T Hirano; R Kobayashi; M Hirano
Journal:  Cell       Date:  1997-05-16       Impact factor: 41.582

3.  A bipolar kinesin.

Authors:  A S Kashina; R J Baskin; D G Cole; K P Wedaman; W M Saxton; J M Scholey
Journal:  Nature       Date:  1996-01-18       Impact factor: 49.962

Review 4.  Long DNA palindromes, cruciform structures, genetic instability and secondary structure repair.

Authors:  D R Leach
Journal:  Bioessays       Date:  1994-12       Impact factor: 4.345

5.  DNA replication triggered by double-stranded breaks in E. coli: dependence on homologous recombination functions.

Authors:  T Asai; D B Bates; T Kogoma
Journal:  Cell       Date:  1994-09-23       Impact factor: 41.582

6.  A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro.

Authors:  T Hirano; T J Mitchison
Journal:  Cell       Date:  1994-11-04       Impact factor: 41.582

7.  DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome.

Authors:  P T Chuang; D G Albertson; B J Meyer
Journal:  Cell       Date:  1994-11-04       Impact factor: 41.582

8.  Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.

Authors:  G E Taccioli; T M Gottlieb; T Blunt; A Priestley; J Demengeot; R Mizuta; A R Lehmann; F W Alt; S P Jackson; P A Jeggo
Journal:  Science       Date:  1994-09-02       Impact factor: 47.728

9.  Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis.

Authors:  Y Saka; T Sutani; Y Yamashita; S Saitoh; M Takeuchi; Y Nakaseko; M Yanagida
Journal:  EMBO J       Date:  1994-10-17       Impact factor: 11.598

10.  ScII: an abundant chromosome scaffold protein is a member of a family of putative ATPases with an unusual predicted tertiary structure.

Authors:  N Saitoh; I G Goldberg; E R Wood; W C Earnshaw
Journal:  J Cell Biol       Date:  1994-10       Impact factor: 10.539
View more
  104 in total

1.  recD sbcB sbcD mutants are deficient in recombinational repair of UV lesions by RecBC.

Authors:  M Seigneur; S D Ehrlich; B Michel
Journal:  J Bacteriol       Date:  1999-10       Impact factor: 3.490

2.  A phylogenomic study of DNA repair genes, proteins, and processes.

Authors:  J A Eisen; P C Hanawalt
Journal:  Mutat Res       Date:  1999-12-07       Impact factor: 2.433

3.  Palindromes as substrates for multiple pathways of recombination in Escherichia coli.

Authors:  G A Cromie; C B Millar; K H Schmidt; D R Leach
Journal:  Genetics       Date:  2000-02       Impact factor: 4.562

4.  The roles of mutS, sbcCD and recA in the propagation of TGG repeats in Escherichia coli.

Authors:  X Pan; D R Leach
Journal:  Nucleic Acids Res       Date:  2000-08-15       Impact factor: 16.971

5.  Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences.

Authors:  Z H Zhou; E Akgūn; M Jasin
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

6.  Instability of repetitive DNA sequences: the role of replication in multiple mechanisms.

Authors:  M Bzymek; S T Lovett
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

7.  Over-representation of repeats in stress response genes: a strategy to increase versatility under stressful conditions?

Authors:  Eduardo P C Rocha; Ivan Matic; François Taddei
Journal:  Nucleic Acids Res       Date:  2002-05-01       Impact factor: 16.971

8.  Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.

Authors:  R S Maser; O K Mirzoeva; J Wells; H Olivares; B R Williams; R A Zinkel; P J Farnham; J H Petrini
Journal:  Mol Cell Biol       Date:  2001-09       Impact factor: 4.272

9.  Evidence for two mechanisms of palindrome-stimulated deletion in Escherichia coli: single-strand annealing and replication slipped mispairing.

Authors:  M Bzymek; S T Lovett
Journal:  Genetics       Date:  2001-06       Impact factor: 4.562

10.  A 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe.

Authors:  Joseph A Farah; Edgar Hartsuiker; Ken-Ichi Mizuno; Kunihiro Ohta; Gerald R Smith
Journal:  Genetics       Date:  2002-05       Impact factor: 4.562
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.