Literature DB >> 9653044

A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection.

T Nagasawa1, K Tachibana, T Kishimoto.   

Abstract

PBSF/SDF-1 is a CXC chemokine which has unique functions among chemokines. It is essential for viability of the embryo, B lymphopoiesis, bone marrow hematopoiesis and cardiogenesis. A receptor for PBSF/SDF-1 was shown to be CXCR4 that is an entry co-receptor for T cell line-tropic HIV-1. Although murine cells had been thought to have no functional co-receptors, murine CXCR4 allowed entry of HIV-1 into target cells with human CD4. In addition, a small molecule CXCR4 inhibitor that blocks HIV-1 entry was identified. Copyright 1998 Academic Press.

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Year:  1998        PMID： 9653044     DOI： 10.1006/smim.1998.0128

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  70 in total

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5.  Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines.

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9.  Phospholipase cbeta is critical for T cell chemotaxis.

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10.  The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions.

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