BACKGROUND & AIMS: A screening policy has not been well defined in first-degree relatives of patients with sporadic colorectal cancer. This study estimated the risk of colorectal adenoma in a cohort of individuals with only 1 affected first-degree relative. METHODS: A total of 476 first-degree relatives (age, 40-74 years) of 195 patients with sporadic colorectal cancer were offered a colonoscopy. Each examined relative was matched with 2 controls for age, sex, symptoms, and center. The prevalence of colorectal adenomas was compared using a multiple logistic regression analysis. RESULTS: In 185 relatives, odds ratios were 1.5 (95% confidence interval [CI], 1.0-2.4) for adenomas, 2.5 for large adenomas (95% CI, 1.1-5.4), 1.2 for small adenomas (95% CI, 0.7-1.9), and 2.6 (95% CI, 1.3-5.1) for high-risk adenomas (> or = 1 cm in size and/or with a villous component). The prevalence of high-risk adenomas in relatives was higher when the index patient was younger than 65 years, was male, and had distal rather than proximal cancer. CONCLUSIONS: Subjects with only 1 affected first-degree relative are at increased risk for developing large adenomas.
BACKGROUND & AIMS: A screening policy has not been well defined in first-degree relatives of patients with sporadic colorectal cancer. This study estimated the risk of colorectal adenoma in a cohort of individuals with only 1 affected first-degree relative. METHODS: A total of 476 first-degree relatives (age, 40-74 years) of 195 patients with sporadic colorectal cancer were offered a colonoscopy. Each examined relative was matched with 2 controls for age, sex, symptoms, and center. The prevalence of colorectal adenomas was compared using a multiple logistic regression analysis. RESULTS: In 185 relatives, odds ratios were 1.5 (95% confidence interval [CI], 1.0-2.4) for adenomas, 2.5 for large adenomas (95% CI, 1.1-5.4), 1.2 for small adenomas (95% CI, 0.7-1.9), and 2.6 (95% CI, 1.3-5.1) for high-risk adenomas (> or = 1 cm in size and/or with a villous component). The prevalence of high-risk adenomas in relatives was higher when the index patient was younger than 65 years, was male, and had distal rather than proximal cancer. CONCLUSIONS: Subjects with only 1 affected first-degree relative are at increased risk for developing large adenomas.
Authors: Deborah W Neklason; Brett L Thorpe; Angel Ferrandez; Anil Tumbapura; Kenneth Boucher; Gilda Garibotti; Richard A Kerber; Cindy H Solomon; Wade S Samowitz; John C Fang; Geraldine P Mineau; Mark F Leppert; Randall W Burt; Scott K Kuwada Journal: Am J Gastroenterol Date: 2008-07-30 Impact factor: 10.864
Authors: Elizabeth T Jacobs; Samir Gupta; John A Baron; Amanda J Cross; David A Lieberman; Gwen Murphy; María Elena Martínez Journal: Am J Gastroenterol Date: 2018-02-20 Impact factor: 10.864
Authors: Diana Redwood; Ellen Provost; Ellen D S Lopez; Monica Skewes; Rhonda Johnson; Claudia Christensen; Frank Sacco; Donald Haverkamp Journal: Health Educ Behav Date: 2015-07-08
Authors: Georgia L Wiesner; Denise Daley; Susan Lewis; Christine Ticknor; Petra Platzer; James Lutterbaugh; Melissa MacMillen; Boris Baliner; Joseph Willis; Robert C Elston; Sanford D Markowitz Journal: Proc Natl Acad Sci U S A Date: 2003-10-17 Impact factor: 11.205