OBJECTIVES: Most colorectal cancers (CRCs) arise from adenomatous polyps, but the effects of CRC family history on adenoma risk are not well known. This issue is clinically relevant since several medical societies currently recommend earlier and more rigorous colorectal screening for individuals with a strong family history of CRC. METHODS: Colonoscopies were performed in 236 first-, second-, and third-degree relatives of 40 index CRC cases from six large kindreds selected from a large population database. The kindreds were selected for significantly greater risk of CRCs compared with the overall population. Known hereditary colon cancer syndromes were clinically and genetically excluded. RESULTS: Thirty-seven percent of relatives were found to have adenomas on colonoscopy. The average age of diagnosis for colon cancer was 63 yr and advanced adenomas 56 yr. Independent predictors of adenomatous polyps in the relatives were advancing age (P < 0.0001), male gender (P < 0.001), and greater degree of relation to CRC cases (P < 0.01). There was no significant predilection of colorectal tumors for the right or left colon. A higher degree of relationship to CRC cases was a significant predictor of having simple and advanced adenomas, but not hyperplastic polyps after adjustment for age and gender. CONCLUSIONS: These data support the current recommendations for colonoscopy starting before the age of 50 yr in individuals with a strong family history of CRC.
OBJECTIVES: Most colorectal cancers (CRCs) arise from adenomatous polyps, but the effects of CRC family history on adenoma risk are not well known. This issue is clinically relevant since several medical societies currently recommend earlier and more rigorous colorectal screening for individuals with a strong family history of CRC. METHODS: Colonoscopies were performed in 236 first-, second-, and third-degree relatives of 40 index CRC cases from six large kindreds selected from a large population database. The kindreds were selected for significantly greater risk of CRCs compared with the overall population. Known hereditary colon cancer syndromes were clinically and genetically excluded. RESULTS: Thirty-seven percent of relatives were found to have adenomas on colonoscopy. The average age of diagnosis for colon cancer was 63 yr and advanced adenomas 56 yr. Independent predictors of adenomatous polyps in the relatives were advancing age (P < 0.0001), male gender (P < 0.001), and greater degree of relation to CRC cases (P < 0.01). There was no significant predilection of colorectal tumors for the right or left colon. A higher degree of relationship to CRC cases was a significant predictor of having simple and advanced adenomas, but not hyperplastic polyps after adjustment for age and gender. CONCLUSIONS: These data support the current recommendations for colonoscopy starting before the age of 50 yr in individuals with a strong family history of CRC.
Authors: Y Mueller-Koch; H Vogelsang; R Kopp; P Lohse; G Keller; D Aust; M Muders; M Gross; J Daum; U Schiemann; M Grabowski; M Scholz; B Kerker; I Becker; G Henke; E Holinski-Feder Journal: Gut Date: 2005-06-14 Impact factor: 23.059
Authors: P Lichtenstein; N V Holm; P K Verkasalo; A Iliadou; J Kaprio; M Koskenvuo; E Pukkala; A Skytthe; K Hemminki Journal: N Engl J Med Date: 2000-07-13 Impact factor: 91.245
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Authors: Deborah W Neklason; Thérèse M Tuohy; Jeffery Stevens; Brith Otterud; Lisa Baird; Richard A Kerber; Wade S Samowitz; Scott K Kuwada; Mark F Leppert; Randall W Burt Journal: J Med Genet Date: 2010-06-03 Impact factor: 6.318
Authors: Scott L DuVall; Alison M Fraser; Kerry Rowe; Alun Thomas; Geraldine P Mineau Journal: J Am Med Inform Assoc Date: 2011-09-16 Impact factor: 4.497
Authors: Deborah W Neklason; Michelle W Done; Nykole R Sargent; Ann G Schwartz; Hoda Anton-Culver; Constance A Griffin; Dennis J Ahnen; Joellen M Schildkraut; Gail E Tomlinson; Louise C Strong; Alexander R Miller; Jill E Stopfer; Randall W Burt Journal: BMC Cancer Date: 2011-10-04 Impact factor: 4.430
Authors: Enrique Quintero; Marta Carrillo; Maria-Liz Leoz; Joaquin Cubiella; Carla Gargallo; Angel Lanas; Luis Bujanda; Antonio Z Gimeno-García; Manuel Hernández-Guerra; David Nicolás-Pérez; Inmaculada Alonso-Abreu; Juan Diego Morillas; Francesc Balaguer; Alfonso Muriel Journal: PLoS Med Date: 2016-05-03 Impact factor: 11.069