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Literature DB >> 9647346

Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways.

Abstract

Receptor-mediated transport mechanisms provide a pathway for the trafficking of extracellular macromolecules into (endocytosis) and across (transcytosis) the cell. This comprises the binding of a ligand to a specific cell-surface receptor, clustering of the ligand-receptor complexes in endocytotic vesicles and vesicular sorting. This review focuses on recent advances in cellular and molecular biology pertaining to receptor-mediated endocytosis. A concise overview is presented of current and potential future applications of targeting to RME mechanisms to improve oral macromolecular drug delivery.

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Year: 1998 PMID： 9647346 DOI： 10.1023/a:1011908128045

Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200

81 in total

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12 in total

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Authors: Aaron C Anselmo; Yatin Gokarn; Samir Mitragotri
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