Dehua Pei1, Marina Buyanova1. 1. Department of Chemistry and Biochemistry , The Ohio State University , 484 West 12th Avenue , Columbus , Ohio 43210 , United States.
Abstract
Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids generally rely on the endocytic pathway as the major uptake mechanism, resulting in their entrapment inside the endosome and lysosome. The recent discovery of cell-penetrating molecules of exceptionally high endosomal escape and cytosolic delivery efficiencies and elucidation of their mechanism of action represent major breakthroughs in this field. In this Topical Review, we provide an overview of the recent progress in understanding and enhancing the endosomal escape process and the new opportunities opened up by these recent findings.
Intracellular delivery of biological agents such as pan class="Chemical">peptides, proteins, and nucleic acids generally rely on the endocytic pathway as the major uptake mechanism, resulting in their entrapn>ment inside the endosome and lysosome. The recent discovery of cell-penetrating molecules of exceptiopan class="Chemical">nally high endosomal escape and cytosolic delivery efficiencies and elucidation of their mechanism of action represent major breakthroughs in this field. In this Topical Review, we provide an overview of the recent progress in understanding and enhancing the endosomal escape process and the new opportunities opened up by these recent findings.
Authors: Betsy A Smith; Douglas S Daniels; Abigail E Coplin; Gregory E Jordan; Lynn M McGregor; Alanna Schepartz Journal: J Am Chem Soc Date: 2008-02-14 Impact factor: 15.419