Literature DB >> 96472

Dopamine metabolites in human brain.

S Wilk, M Stanley.   

Abstract

The relationship of human brain levels of 3,4-dihydroxyphenylacetic acid (DOPAC) to cerebrospinal fluid levels of this domapine (DA) metabolite was studied. The effect of postmortem delay was evaluated in the rat. DOPAC was resistant to postmortem changes in brain kept in situ. The level of DOPAC (free and conjugated) determined in DA-rich areas of six human brains amounted to only a fraction of the homovanillic acid (HVA) found in the same regions. The DOPAC/HVA ratio in human brain was similar to that found in CSF. We conclude that HVA is the major DA metabolite in human brain and that DA metabolite levels in CSF reflect DA metabolite levels in brain.

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Year:  1978        PMID： 96472     DOI： 10.1007/bf00426961

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  15 in total

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Authors:  H BERNHEIMER
Journal:  Nature       Date:  1964-11-07       Impact factor: 49.962

2.  Postmortem stability of norepinephrine, dopamine, and serotonin in rat brain.

Authors:  R S Sloviter; J D Connor
Journal:  J Neurochem       Date:  1977-05       Impact factor: 5.372

3.  Post-mortal changes of dopamine and homovanillic acid levels in rat striatum as measured by mass fragmentography.

Authors:  F A Wiesel; G Sedvall
Journal:  Brain Res       Date:  1974-01-18       Impact factor: 3.252

4.  Postmortal accumulation of 3-methoxytyramine in brain.

Authors:  A Carlsson; M Lindqvist; W Kehr
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

5.  Simultaneous determination of 3,4-dihydroxyphenylacetic acid and homovanillic acid in milligram amounts of rat striatal tissue by gas-liquid chromatography.

Authors:  E Watson; B Travis; S Wilk
Journal:  Life Sci       Date:  1974-12-15       Impact factor: 5.037

6.  Assessment of cerebrospinal fluid levels of dopamine metabolites by gas chromatography.

Authors:  E Watson; S Wilk
Journal:  Psychopharmacologia       Date:  1975-04-30

7.  Evaluation of dopamine metabolism in rat striatum by a gas chromatographic technique.

Authors:  S Wilk; E Watson; B Travis
Journal:  Eur J Pharmacol       Date:  1975-02       Impact factor: 4.432

8.  3,4-Dihydroxyphenylacetic acid and homovanillic acid in serum and cerebrospinal fluid of psychotic patients estimated by a gas chromatographic method.

Authors:  E S Markianos; E Rüther; H Gluba
Journal:  Neurosci Lett       Date:  1976-09       Impact factor: 3.046

9.  Determination of conjugated monoamine metabolites in brain tissue.

Authors:  C G Swahn; F A Wiesel
Journal:  J Neural Transm       Date:  1976       Impact factor: 3.575

10.  Dihydroxyphenylacetic acid conjugate: natural occurrence and demonstration of probenecid-induced accumulation in rat striatum, olfactory tubercles and frontal cortex.

Authors:  M A Elchisak; J W Maas; R H Roth
Journal:  Eur J Pharmacol       Date:  1977-02-21       Impact factor: 4.432
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  5 in total

1.  Concentration of homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular cerebrospinal fluid of patients with obstructive hydrocephalus.

Authors:  K Kmieciak-Kolada; H Majchrzak; Z S Herman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1979-01       Impact factor: 10.154

2.  Decreased vesicular storage and aldehyde dehydrogenase activity in multiple system atrophy.

Authors:  David S Goldstein; Patricia Sullivan; Courtney Holmes; Irwin J Kopin; Yehonatan Sharabi; Deborah C Mash
Journal:  Parkinsonism Relat Disord       Date:  2015-03-20       Impact factor: 4.891

3.  Regional studies of serotonin and dopamine metabolism and quantification of serotonin uptake sites in human cerebral cortex.

Authors:  B Parsons; A Roxas; Y Y Huang; A Dwork; M Stanley
Journal:  J Neural Transm Gen Sect       Date:  1992

4.  The novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide decreases nicotine-induced dopamine metabolism in rat nucleus accumbens.

Authors:  Shafiqur Rahman; Nichole M Neugebauer; Zhenfa Zhang; Peter A Crooks; Linda P Dwoskin; Michael T Bardo
Journal:  Eur J Pharmacol       Date:  2008-10-26       Impact factor: 4.432

5.  Antagonistic effect of dopamine structural analogues on human GABAρ1 receptor.

Authors:  Alfredo Alaniz-Palacios; Ataulfo Martínez-Torres
Journal:  Sci Rep       Date:  2017-12-12       Impact factor: 4.379
  5 in total

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