Literature DB >> 9637239

Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA.

S Dinglay1, B Gold, B Sedgwick.   

Abstract

Escherichia coli alkB mutants are sensitive to methyl methanesulfonate and dimethylsulphate, and are defective in the processing of methylated DNA. The function of the AlkB protein has not been determined. Here, we show that alkB mutants are not defective in repairing several different types of potentially toxic DNA lesions that are known to be generated by MMS, including apyrimidinic and apurinic sites, and secondary lesions that could arise at these sites (DNA-protein cross-links and DNA interstrand cross-links). Also, alkB mutants were not sensitive to MeOSO2-(CH2)2-Lex, a compound that alkylates the minor groove of DNA generating primarily 3-methyladenine.

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Year:  1998        PMID： 9637239     DOI： 10.1016/s0921-8777(97)00065-7

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  11 in total

1.  Regulatory responses of the adaptive response to alkylation damage: a simple regulon with complex regulatory features.

Authors:  P Landini; M R Volkert
Journal:  J Bacteriol       Date:  2000-12       Impact factor: 3.490

Review 2.  Direct reversal of DNA alkylation damage.

Authors:  Yukiko Mishina; Erica M Duguid; Chuan He
Journal:  Chem Rev       Date:  2006-02       Impact factor: 60.622

Review 3.  Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.

Authors:  Yukiko Mishina; Chuan He
Journal:  J Inorg Biochem       Date:  2006-02-15       Impact factor: 4.155

4.  XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine.

Authors:  Debora Russo; Gilberto Fronza; Laura Ottaggio; Paola Monti; Chiara Perfumo; Alberto Inga; Prema Iyer; Barry Gold; Paola Menichini
Journal:  DNA Repair (Amst)       Date:  2010-05-14

5.  Defective processing of methylated single-stranded DNA by E. coli AlkB mutants.

Authors:  S Dinglay; S C Trewick; T Lindahl; B Sedgwick
Journal:  Genes Dev       Date:  2000-08-15       Impact factor: 11.361

6.  Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage.

Authors:  Yu Xu; Akanksha Manghrani; Bei Liu; Honglue Shi; Uyen Pham; Amy Liu; Hashim M Al-Hashimi
Journal:  J Biol Chem       Date:  2020-09-10       Impact factor: 5.157

7.  A non-heme iron-mediated chemical demethylation in DNA and RNA.

Authors:  Chengqi Yi; Cai-Guang Yang; Chuan He
Journal:  Acc Chem Res       Date:  2009-04-21       Impact factor: 22.384

8.  High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.

Authors:  Debora Russo; Gilberto Fronza; Laura Ottaggio; Paola Monti; Alberto Inga; Prema Iyer; Barry Gold; Paola Menichini
Journal:  Mutat Res       Date:  2009-09-01       Impact factor: 2.433

Review 9.  How do cells cope with RNA damage and its consequences?

Authors:  Liewei L Yan; Hani S Zaher
Journal:  J Biol Chem       Date:  2019-08-22       Impact factor: 5.157

Review 10.  Nucleic acid oxidation in DNA damage repair and epigenetics.

Authors:  Guanqun Zheng; Ye Fu; Chuan He
Journal:  Chem Rev       Date:  2014-02-28       Impact factor: 60.622
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