Literature DB >> 9631653

My favorite cell: Giardia.

J Upcroft1, P Upcroft.   

Abstract

The gut protozoan parasite, Giardia duodenalis, is the best characterized example of the most ancient eukaryotes, which are anaerobic and appear to be primitively amitochondrial. Apart from its obvious medical importance, Giardia is fascinating in its own right. Its prokaryotic-like anaerobic metabolism renders it selectively sensitive to some bacterial drugs, especially the nitroimidazoles, which are activated to form toxic radicals. Other features, including an enzyme that reduces oxygen directly to water, cysteine as the keeper of redox balance, a plasmid, and toxin-like genes are also distinctly prokaryotic-like. But, unlike prokaryotes, Giardia has a sophisticated, highly developed cytoskeleton, bounded nuclei, linear chromosomes capped with telomeric repeats, and telomere positional regulation of gene expression.

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Year:  1998        PMID: 9631653     DOI: 10.1002/(SICI)1521-1878(199803)20:3<256::AID-BIES9>3.0.CO;2-P

Source DB:  PubMed          Journal:  Bioessays        ISSN: 0265-9247            Impact factor:   4.345


  23 in total

1.  In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells.

Authors:  Joachim Müller; Géraldine Rühle; Norbert Müller; Jean-François Rossignol; Andrew Hemphill
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

2.  Central importance of immunoglobulin A in host defense against Giardia spp.

Authors:  T Dianne Langford; Michael P Housley; Marianne Boes; Jianzhu Chen; Martin F Kagnoff; Frances D Gillin; Lars Eckmann
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

Review 3.  Chromosome sequence maps of the Giardia lamblia assemblage A isolate WB.

Authors:  Jacqui A Upcroft; Kenia G Krauer; Peter Upcroft
Journal:  Trends Parasitol       Date:  2010-08-24

Review 4.  Drug targets and mechanisms of resistance in the anaerobic protozoa.

Authors:  P Upcroft; J A Upcroft
Journal:  Clin Microbiol Rev       Date:  2001-01       Impact factor: 26.132

Review 5.  Treatment of giardiasis.

Authors:  T B Gardner; D R Hill
Journal:  Clin Microbiol Rev       Date:  2001-01       Impact factor: 26.132

6.  A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides.

Authors:  Joachim Müller; Jonathan Wastling; Sanya Sanderson; Norbert Müller; Andrew Hemphill
Journal:  Antimicrob Agents Chemother       Date:  2007-04-16       Impact factor: 5.191

7.  Barcoding of Giardia duodenalis isolates and derived lines from an established cryobank by a mutation scanning-based approach.

Authors:  Matthew J Nolan; Aaron R Jex; Jacqui A Upcroft; Peter Upcroft; Robin B Gasser
Journal:  Electrophoresis       Date:  2011-08       Impact factor: 3.535

8.  Giardia lamblia: behavior of the nuclear envelope.

Authors:  Marlene Benchimol
Journal:  Parasitol Res       Date:  2004-10       Impact factor: 2.289

9.  Goblet cells: are they an unspecific barrier against Giardia intestinalis or a gate?

Authors:  Martha Ponce-Macotela; Angélica González-Maciel; Rafael Reynoso-Robles; Mario N Martínez-Gordillo
Journal:  Parasitol Res       Date:  2007-11-25       Impact factor: 2.289

10.  Pulsed electron paramagnetic resonance experiments identify the paramagnetic intermediates in the pyruvate ferredoxin oxidoreductase catalytic cycle.

Authors:  Andrei V Astashkin; Javier Seravalli; Steven O Mansoorabadi; George H Reed; Stephen W Ragsdale
Journal:  J Am Chem Soc       Date:  2006-03-29       Impact factor: 15.419

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