Literature DB >> 9631006

Refining the telomere-telomerase hypothesis of aging and cancer.

S E Holt1, J W Shay, W E Wright.   

Abstract

While there has been substantial experimental evidence in support of the telomere-telomerase hypothesis of aging and cancer, it has been suggested that the theory has been oversimplified to the exclusion of alternative mechanisms in the progression of cancer. This review strives to present an overview of some of the areas that have not been well explained and to indicate where multiple interpretations of the data are possible.

Entities:  

Mesh:

Substances:

Year:  1996        PMID: 9631006     DOI: 10.1038/nbt0796-836

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN: 1087-0156            Impact factor:   54.908


  32 in total

1.  Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro.

Authors:  L Lacroix; H Liénard; E Labourier; M Djavaheri-Mergny; J Lacoste; H Leffers; J Tazi; C Hélène; J L Mergny
Journal:  Nucleic Acids Res       Date:  2000-04-01       Impact factor: 16.971

Review 2.  Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology.

Authors:  J Fajkus; M Simícková; J Maláska
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2002-04-29       Impact factor: 6.237

3.  Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci.

Authors:  Hong Zhang; Kuang-Hung Pan; Stanley N Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-07       Impact factor: 11.205

4.  Effect of antisense oligodeoxynucleotide of telomerase RNA on telomerase activity and cell apoptosis in human colon cancer.

Authors:  Ying-An Jiang; He-Sheng Luo; Li-Fang Fan; Chong-Qing Jiang; Wei-Jin Chen
Journal:  World J Gastroenterol       Date:  2004-02-01       Impact factor: 5.742

5.  Smurf2 up-regulation activates telomere-dependent senescence.

Authors:  Hong Zhang; Stanley N Cohen
Journal:  Genes Dev       Date:  2004-12-01       Impact factor: 11.361

Review 6.  Dysregulation of T-cell function in the elderly : scientific basis and clinical implications.

Authors:  Tamas Fulop; Anis Larbi; Anders Wikby; Eugenio Mocchegiani; Katsuiku Hirokawa; Graham Pawelec
Journal:  Drugs Aging       Date:  2005       Impact factor: 3.923

7.  DNA damage, DNA repair, ageing and age-related disease.

Authors:  David M Wilson; Vilhelm A Bohr; Peter J McKinnon
Journal:  Mech Ageing Dev       Date:  2008-03-04       Impact factor: 5.432

8.  Telomerase activity and cell apoptosis in colon cancer cell by human telomerase reverse transcriptase gene antisense oligodeoxynucleotide.

Authors:  Ying-An Jiang; He-Sheng Luo; You-Yuan Zhang; Li-Fang Fan; Chong-Qing Jiang; Wei-Jin Chen
Journal:  World J Gastroenterol       Date:  2003-09       Impact factor: 5.742

9.  Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT).

Authors:  Hirotaka Nishi; Toshihide Nakada; Satoru Kyo; Masaki Inoue; Jerry W Shay; Keiichi Isaka
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

Review 10.  Therapeutic strategies targeting cancer stem cells.

Authors:  Xiaoyan Ning; Jianchang Shu; Yiqi Du; Qiwen Ben; Zhaoshen Li
Journal:  Cancer Biol Ther       Date:  2013-01-28       Impact factor: 4.742

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.