OBJECTIVE: To evaluate whether the predictive ability of a normal FSH level on cycle day 3 can be enhanced by levels of estradiol-17beta (E2) on cycle day 3. DESIGN: Prospective cohort study. SETTING: University hospital-based, tertiary care infertility center. PATIENT(S): Two hundred thirty-one consecutively seen patients who attended the center for their first IVF attempt. INTERVENTION(S): Blood samples were collected on day 3 of the cycle preceding IVF; IVF was performed in all patients. MAIN OUTCOME MEASURE(S): Patient's age, number of ampules of hMG, cancellation rate, number of oocytes, fertilization rate, and clinical pregnancy rate. RESULT(S): In patients with elevated FSH levels on cycle day 3, a low oocyte yield was achieved (7 versus 11) and a high number of ampules of hMG was necessary (56 versus 33). Their cancellation rate was high (67% versus 16%). In patients with normal basal FSH levels, high E2 levels predicted a high cancellation rate (56%, versus 13% in patients with low E2 levels) and a low oocyte yield (9, versus 11 in patients with low E2 levels). Patients with both normal FSH levels and low E2 levels on cycle day 3 fared best. CONCLUSION(S): The basal E2 level on cycle day 3 is a useful prognosticator of response to stimulation in IVF patients with normal basal FSH levels.
OBJECTIVE: To evaluate whether the predictive ability of a normal FSH level on cycle day 3 can be enhanced by levels of estradiol-17beta (E2) on cycle day 3. DESIGN: Prospective cohort study. SETTING: University hospital-based, tertiary care infertility center. PATIENT(S): Two hundred thirty-one consecutively seen patients who attended the center for their first IVF attempt. INTERVENTION(S): Blood samples were collected on day 3 of the cycle preceding IVF; IVF was performed in all patients. MAIN OUTCOME MEASURE(S): Patient's age, number of ampules of hMG, cancellation rate, number of oocytes, fertilization rate, and clinical pregnancy rate. RESULT(S): In patients with elevated FSH levels on cycle day 3, a low oocyte yield was achieved (7 versus 11) and a high number of ampules of hMG was necessary (56 versus 33). Their cancellation rate was high (67% versus 16%). In patients with normal basal FSH levels, high E2 levels predicted a high cancellation rate (56%, versus 13% in patients with low E2 levels) and a low oocyte yield (9, versus 11 in patients with low E2 levels). Patients with both normal FSH levels and low E2 levels on cycle day 3 fared best. CONCLUSION(S): The basal E2 level on cycle day 3 is a useful prognosticator of response to stimulation in IVFpatients with normal basal FSH levels.
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