| Literature DB >> 9625049 |
M Kamberi1, K Tsutsumi, T Kotegawa, K Nakamura, S Nakano.
Abstract
A simple, sensitive isocratic method for the detection and quantification of ciprofloxacin in plasma and urine has been developed. The assay consisted of reversed-phase HPLC with ultraviolet detection. Plasma proteins were removed by a fast and efficient procedure. For the urine samples, the only required sample preparation was dilution. Separation was achieved on a C18 reversed-phase column. The quantification limit was 0.01 mg/L in plasma and 0.5 mg/L in urine. This method was sufficiently sensitive for pharmacokinetic studies.Entities:
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Year: 1998 PMID： 9625049
Source DB: PubMed Journal: Clin Chem ISSN： 0009-9147 Impact factor: 8.327