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Literature DB >> 9624502

Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro.

S Kawasaki¹, H Takizawa, T Ohtoshi, N Takeuchi, T Kohyama, H Nakamura, T Kasama, K Kobayashi, K Nakahara, Y Morita, K Yamamoto.

Abstract

We evaluated the effect of roxithromycin on cytokine production and neutrophil attachment to human airway epithelial cells. Roxithromycin suppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-macrophage colony-stimulating factor. It inhibited neutrophil adhesion to epithelial cells. Roxithromycin modulates local recruitment and activation of inflammatory cells, which may have relevance to its efficacy in airway diseases.

Entities: Chemical Gene Species

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Year: 1998 PMID： 9624502 PMCID： PMC105630

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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