Literature DB >> 9624499

Efficacies of zinc-finger-active drugs against Giardia lamblia.

T Nash1, W G Rice.   

Abstract

Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 microM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 +/- 0.32 microM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.

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Year:  1998        PMID： 9624499      PMCID： PMC105627     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.

Authors:  W G Rice; J G Supko; L Malspeis; R W Buckheit; D Clanton; M Bu; L Graham; C A Schaeffer; J A Turpin; J Domagala; R Gogliotti; J P Bader; S M Halliday; L Coren; R C Sowder; L O Arthur; L E Henderson
Journal:  Science       Date:  1995-11-17       Impact factor: 47.728

2.  Antigenic variation in Giardia lamblia.

Authors:  T E Nash; A Aggarwal; R D Adam; J T Conrad; J W Merritt
Journal:  J Immunol       Date:  1988-07-15       Impact factor: 5.422

3.  Restriction-endonuclease analysis of DNA from 15 Giardia isolates obtained from humans and animals.

Authors:  T E Nash; T McCutchan; D Keister; J B Dame; J D Conrad; F D Gillin
Journal:  J Infect Dis       Date:  1985-07       Impact factor: 5.226

4.  Effects of diethyldithiocarbamate and structural analogs in mice with systemic candidal infections.

Authors:  E M Walker; D J Cannon; M E Reifsteck; K A Hobbs; H F Hardin; M M Jones; J K Skeeles
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1987-05

5.  Giardia lamblia infections in adult mice.

Authors:  L G Byrd; J T Conrad; T E Nash
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

6.  Isolation and expression of the gene for a major surface protein of Giardia lamblia.

Authors:  F D Gillin; P Hagblom; J Harwood; S B Aley; D S Reiner; M McCaffery; M So; D G Guiney
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

7.  Carboxy-terminal sequence conservation among variant-specific surface proteins of Giardia lamblia.

Authors:  M R Mowatt; A Aggarwal; T E Nash
Journal:  Mol Biochem Parasitol       Date:  1991-12       Impact factor: 1.759

8.  Tetraethylthiuram disulfide (Antabuse) inhibits the human malaria parasite Plasmodium falciparum.

Authors:  L W Scheibel; A Adler; W Trager
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

9.  Cysteine-dependent zinc binding by membrane proteins of Giardia lamblia.

Authors:  Y Y Zhang; S B Aley; S L Stanley; F D Gillin
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

10.  Purification of a variant-specific surface protein of Giardia lamblia and characterization of its metal-binding properties.

Authors:  H D Luján; M R Mowatt; J J Wu; Y Lu; A Lees; M R Chance; T E Nash
Journal:  J Biol Chem       Date:  1995-06-09       Impact factor: 5.157
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  20 in total

1.  Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.

Authors:  Emina Jukic; Michael Blatzer; Wilfried Posch; Marion Steger; Ulrike Binder; Cornelia Lass-Flörl; Doris Wilflingseder
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

2.  Discovery of novel antigiardiasis drug candidates.

Authors:  Liudmila Kulakova; Andrey Galkin; Catherine Z Chen; Noel Southall; Juan J Marugan; Wei Zheng; Osnat Herzberg
Journal:  Antimicrob Agents Chemother       Date:  2014-09-29       Impact factor: 5.191

3.  Validity of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents.

Authors:  D E Said; L M Elsamad; Y M Gohar
Journal:  Parasitol Res       Date:  2012-03-06       Impact factor: 2.289

4.  Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

Authors:  Yasuhiro Horita; Takemasa Takii; Tetsuya Yagi; Kenji Ogawa; Nagatoshi Fujiwara; Emi Inagaki; Laurent Kremer; Yasuo Sato; Ryuji Kuroishi; Yoosa Lee; Toshiaki Makino; Hajime Mizukami; Tomohiro Hasegawa; Ryuji Yamamoto; Kikuo Onozaki
Journal:  Antimicrob Agents Chemother       Date:  2012-05-21       Impact factor: 5.191

Review 5.  Treatment of giardiasis.

Authors:  T B Gardner; D R Hill
Journal:  Clin Microbiol Rev       Date:  2001-01       Impact factor: 26.132

6.  Structural basis for inactivation of Giardia lamblia carbamate kinase by disulfiram.

Authors:  Andrey Galkin; Liudmila Kulakova; Kap Lim; Catherine Z Chen; Wei Zheng; Illarion V Turko; Osnat Herzberg
Journal:  J Biol Chem       Date:  2014-02-20       Impact factor: 5.157

7.  A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia.

Authors:  Noa Tejman-Yarden; Yukiko Miyamoto; David Leitsch; Jennifer Santini; Anjan Debnath; Jiri Gut; James H McKerrow; Sharon L Reed; Lars Eckmann
Journal:  Antimicrob Agents Chemother       Date:  2013-02-12       Impact factor: 5.191

8.  Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions.

Authors:  Alex G Peniche; Adam R Renslo; Peter C Melby; Bruno L Travi
Journal:  Antimicrob Agents Chemother       Date:  2015-08-03       Impact factor: 5.191

9.  The old and new therapeutic approaches to the treatment of giardiasis: where are we?

Authors:  Haendel G N O Busatti; Joseph F G Santos; Maria A Gomes
Journal:  Biologics       Date:  2009-07-13

10.  The genome of the blood fluke Schistosoma mansoni.

Authors:  Matthew Berriman; Brian J Haas; Philip T LoVerde; R Alan Wilson; Gary P Dillon; Gustavo C Cerqueira; Susan T Mashiyama; Bissan Al-Lazikani; Luiza F Andrade; Peter D Ashton; Martin A Aslett; Daniella C Bartholomeu; Gaelle Blandin; Conor R Caffrey; Avril Coghlan; Richard Coulson; Tim A Day; Art Delcher; Ricardo DeMarco; Appolinaire Djikeng; Tina Eyre; John A Gamble; Elodie Ghedin; Yong Gu; Christiane Hertz-Fowler; Hirohisha Hirai; Yuriko Hirai; Robin Houston; Alasdair Ivens; David A Johnston; Daniela Lacerda; Camila D Macedo; Paul McVeigh; Zemin Ning; Guilherme Oliveira; John P Overington; Julian Parkhill; Mihaela Pertea; Raymond J Pierce; Anna V Protasio; Michael A Quail; Marie-Adèle Rajandream; Jane Rogers; Mohammed Sajid; Steven L Salzberg; Mario Stanke; Adrian R Tivey; Owen White; David L Williams; Jennifer Wortman; Wenjie Wu; Mostafa Zamanian; Adhemar Zerlotini; Claire M Fraser-Liggett; Barclay G Barrell; Najib M El-Sayed
Journal:  Nature       Date:  2009-07-16       Impact factor: 49.962
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