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Literature DB >> 962423

4-nitro-2-phenoxymethanesulfonanilide (R-805): a chemically novel anti-inflammatory agent.

Abstract

The anti-inflammatory activity of the sulfonanilide, 4-nitro-2-phenoxymethanesulfonanilide (R-805) has been demonstrated in conventional models (carrageenan-induced edema of the rat's paw, UV-induced erythema of guinea-pig skin, adjuvant-induced arthritis of the rat). R-805 differs from most currently available acidic anti-inflammatory drugs in that its functional acidic group is not carboxyl. The relative anti-inflammatory potency of R-805 is comparable to indomethacin. Calculation of acute therapeutic indices (LD50/ED50) for 8 acidic anti-inflammatory drugs show R-805 to possess a more favourable index than the other drugs examined.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1976 PMID： 962423

Source DB: PubMed Journal: Arch Int Pharmacodyn Ther ISSN： 0003-9780

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Cited

20 in total

1. Automated docking and molecular dynamics simulations of nimesulide in the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 (COX-2).

Authors: R García-Nieto; C Pérez; F Gago
Journal: J Comput Aided Mol Des Date: 2000-02 Impact factor: 3.686

2. Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.

Authors: Hui-Hua Chang; Zuohe Song; Lee Wisner; Tina Tripp; Vijay Gokhale; Emmanuelle J Meuillet
Journal: Invest New Drugs Date: 2011-09-20 Impact factor: 3.850

3. A multicentre double-blind investigation comparing nimesulide and naproxen in the treatment of minor sport injuries.

Authors: A Calligaris; I Scaricabarozzi; L Vecchiet
Journal: Drugs Date: 1993 Impact factor: 9.546

4. A controlled clinical study of the efficacy and tolerability of nimesulide vs naproxen in maxillo-facial surgery.

Authors: G Ferrari Parabita; U Zanetti; F Scalvini; D Rossi; I Scaricabarozzi
Journal: Drugs Date: 1993 Impact factor: 9.546

Review 5. Cyclo-oxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs.

Authors: J Y Jouzeau; B Terlain; A Abid; E Nédélec; P Netter
Journal: Drugs Date: 1997-04 Impact factor: 9.546

Review 6. Nimesulide. A preliminary review of its pharmacological properties and therapeutic efficacy in inflammation and pain states.

Authors: A Ward; R N Brogden
Journal: Drugs Date: 1988-12 Impact factor: 9.546

4-nitro-2-phenoxymethanesulfonanilide (R-805): a chemically novel anti-inflammatory agent.

1. Automated docking and molecular dynamics simulations of nimesulide in the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 (COX-2).

2. Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.

3. A multicentre double-blind investigation comparing nimesulide and naproxen in the treatment of minor sport injuries.

4. A controlled clinical study of the efficacy and tolerability of nimesulide vs naproxen in maxillo-facial surgery.

Review 5. Cyclo-oxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs.

Review 6. Nimesulide. A preliminary review of its pharmacological properties and therapeutic efficacy in inflammation and pain states.

7. Nimesulide inhibits platelet-activating factor synthesis in activated human neutrophils.

8. Controlled clinical studies of nimesulide in the treatment of urogenital inflammation.

Review 9. The effect of nimesulide on prostanoid formation.

Review 10. Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide.