Literature DB >> 7506143

The effect of nimesulide on prostanoid formation.

E Magni1.   

Abstract

Nimesulide (4-nitro-2-phenoxy-methansulfonanilide) is a weak acidic (pKa = 6.50) nonsteroidal anti-inflammatory drug (NSAID) belonging to a new chemical class, the sulfonanilide derivatives, and does not contain the carboxylic group. It exhibits potent anti-inflammatory, analgesic and antipyretic activities. Although nimesulide is not a cyclo-oxygenase inhibitor in gastric tissues or bovine seminal vesicle microsomes, it inhibits prostaglandin synthesis in zymosan-stimulated murine macrophages in inflammatory exudate. Nimesulide significantly antagonises the immune formation of thromboxane B2 in lung tissue. It neither induces gastrointestinal lesions nor affects renal function in animal models.

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Year:  1993        PMID： 7506143     DOI： 10.2165/00003495-199300461-00004

Source DB:  PubMed          Journal:  Drugs        ISSN： 0012-6667            Impact factor:   9.546


  10 in total

1.  Inhibition of neutrophil oxidative metabolism by nimesulide.

Authors:  F Capsoni; E Venegoni; F Minonzio; A M Ongari; V Maresca; C Zanussi
Journal:  Agents Actions       Date:  1987-06

2.  The anti-inflammatory drug nimesulide rescues alpha-1-proteinase inhibitor from oxidative inactivation by phagocytosing neutrophils.

Authors:  F Dallegri; L Ottonello; P Dapino; M Bevilacqua
Journal:  Respiration       Date:  1992       Impact factor: 3.580

3.  Inactivation of neutrophil-derived hypochlorous acid by nimesulide: a potential mechanism for the tissue protection during inflammation.

Authors:  F Dallegri; F Patrone; A Ballestrero; L Ottonello; F Ferrando; C Sacchetti
Journal:  Int J Tissue React       Date:  1990

4.  Comparison of the systemic inhibition of thromboxane synthesis, anti-inflammatory activity and gastro-intestinal toxicity of non-steroidal anti-inflammatory drugs in the rat.

Authors:  D P Carr; R Henn; J R Green; I Böttcher
Journal:  Agents Actions       Date:  1986-12

5.  Mechanism of action of novel anti-inflammmatory drugs diflumidone and R-805.

Authors:  R L Vigdahl; R H Tukey
Journal:  Biochem Pharmacol       Date:  1977-02-15       Impact factor: 5.858

6.  The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs.

Authors:  K D Rainsford
Journal:  Agents Actions       Date:  1977-12

7.  4-nitro-2-phenoxymethanesulfonanilide (R-805): a chemically novel anti-inflammatory agent.

Authors:  K F Swingle; G G Moore; T J Grant
Journal:  Arch Int Pharmacodyn Ther       Date:  1976-05

8.  Antianaphylactic and antihistaminic activity of the non-steroidal anti-inflammatory compound nimesulide in guinea-pig.

Authors:  F Berti; G Rossoni; A Buschi; M Robuschi; L M Villa
Journal:  Arzneimittelforschung       Date:  1990-09

9.  A sulphonamido-indanone derivative CGP 28237 (ZK 34228), a novel non-steroidal anti-inflammatory agent without gastro-intestinal ulcerogenicity in rats.

Authors:  I Böttcher; A Schweizer; M Glatt; H Werner
Journal:  Drugs Exp Clin Res       Date:  1987

10.  Non-steroidal anti-inflammatories--XII. Mode of action of anti-inflammatory methane sulfonanilides.

Authors:  C Rufer; E Schillinger; I Böttcher; W Repenthin; C Herrmann
Journal:  Biochem Pharmacol       Date:  1982-11-15       Impact factor: 5.858
  10 in total
  7 in total

Review 1.  The importance of COX-2 inhibition for aspirin induced asthma.

Authors:  A Bennett
Journal:  Thorax       Date:  2000-10       Impact factor: 9.139

Review 2.  Cyclo-oxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs.

Authors:  J Y Jouzeau; B Terlain; A Abid; E Nédélec; P Netter
Journal:  Drugs       Date:  1997-04       Impact factor: 9.546

Review 3.  Adverse drug events related to dosage forms and delivery systems.

Authors:  I F Uchegbu; A T Florence
Journal:  Drug Saf       Date:  1996-01       Impact factor: 5.606

4.  The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis-induced monoarticular arthritis in the rat.

Authors:  D W Gilroy; A Tomlinson; K Greenslade; M P Seed; D A Willoughby
Journal:  Inflammation       Date:  1998-10       Impact factor: 4.092

5.  An analysis from clinico-epidemiological data of the principal adverse events from the COX-2 selective NSAID, nimesulide, with particular reference to hepatic injury.

Authors:  K D Rainsford
Journal:  Inflammopharmacology       Date:  1998       Impact factor: 4.473

6.  A Double-Blind Study Comparing Nimesulide with Naproxen in the Treatment of Osteoarthritis of the Hip.

Authors:  M Quattrini; S Paladin
Journal:  Clin Drug Investig       Date:  1995-09       Impact factor: 2.859

Review 7.  Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.

Authors:  R Davis; R N Brogden
Journal:  Drugs       Date:  1994-09       Impact factor: 9.546
  7 in total

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