Literature DB >> 9621908

Dynamics of blood flow and oxygenation changes during brain activation: the balloon model.

R B Buxton1, E C Wong, L R Frank.   

Abstract

A biomechanical model is presented for the dynamic changes in deoxyhemoglobin content during brain activation. The model incorporates the conflicting effects of dynamic changes in both blood oxygenation and blood volume. Calculations based on the model show pronounced transients in the deoxyhemoglobin content and the blood oxygenation level dependent (BOLD) signal measured with functional MRI, including initial dips and overshoots and a prolonged poststimulus undershoot of the BOLD signal. Furthermore, these transient effects can occur in the presence of tight coupling of cerebral blood flow and oxygen metabolism throughout the activation period. An initial test of the model against experimental measurements of flow and BOLD changes during a finger-tapping task showed good agreement.

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Year:  1998        PMID： 9621908     DOI： 10.1002/mrm.1910390602

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  438 in total

1.  Nonlinear temporal dynamics of the cerebral blood flow response.

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Review 3.  Statistical limitations in functional neuroimaging. I. Non-inferential methods and statistical models.

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4.  Motion opponency in visual cortex.

Authors:  D J Heeger; G M Boynton; J B Demb; E Seidemann; W T Newsome
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Review 5.  On the relation between brain images and brain neural networks.

Authors:  J G Taylor; B Krause; N J Shah; B Horwitz; H W Mueller-Gaertner
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6.  New insights into the hemodynamic blood oxygenation level-dependent response through combination of functional magnetic resonance imaging and optical recording in gerbil barrel cortex.

Authors:  A Hess; D Stiller; T Kaulisch; P Heil; H Scheich
Journal:  J Neurosci       Date:  2000-05-01       Impact factor: 6.167

7.  A 4D approach to the analysis of functional brain images: application to FMRI data.

Authors:  A Ledberg; P Fransson; J Larsson; K M Petersson
Journal:  Hum Brain Mapp       Date:  2001-08       Impact factor: 5.038

8.  Early discrimination of coherent versus incoherent motion by multiunit and synaptic activity in human putative MT+.

Authors:  I Ulbert; G Karmos; G Heit; E Halgren
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9.  Feature-space clustering for fMRI meta-analysis.

Authors:  C Goutte; L K Hansen; M G Liptrot; E Rostrup
Journal:  Hum Brain Mapp       Date:  2001-07       Impact factor: 5.038

Review 10.  The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements.

Authors:  Hana Uhlirova; Kıvılcım Kılıç; Peifang Tian; Sava Sakadžić; Louis Gagnon; Martin Thunemann; Michèle Desjardins; Payam A Saisan; Krystal Nizar; Mohammad A Yaseen; Donald J Hagler; Matthieu Vandenberghe; Srdjan Djurovic; Ole A Andreassen; Gabriel A Silva; Eliezer Masliah; David Kleinfeld; Sergei Vinogradov; Richard B Buxton; Gaute T Einevoll; David A Boas; Anders M Dale; Anna Devor
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-10-05       Impact factor: 6.237
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