Literature DB >> 9621095

Cloning and functional analysis of Kaposi's sarcoma-associated herpesvirus DNA polymerase and its processivity factor.

K Lin1, C Y Dai, R P Ricciardi.   

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, is a newly identified virus with tumorigenic potential. Here, we cloned and expressed the DNA polymerase (Pol-8) of KSHV and its processivity factor (PF-8). Pol-8 bound specifically to PF-8 in vitro. Moreover, the DNA synthesis activity of Pol-8 was shown in vitro to be strongly dependent on PF-8. Addition of PF-8 to Pol-8 allowed efficient synthesis of fully extended DNA products corresponding to the full-length M13 template (7,249 nucleotides), whereas Pol-8 alone could incorporate only several nucleotides. The specificity of PF-8 and Pol-8 for each other was demonstrated by their inability to be functionally replaced by the DNA polymerases and processivity factors of herpes simplex virus 1 and human herpesvirus 6.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9621095      PMCID： PMC110445     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  Functional analysis of the herpes simplex virus UL42 protein.

Authors:  P Digard; C S Chow; L Pirrit; D M Coen
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

2.  Functional interaction between Epstein-Barr virus DNA polymerase catalytic subunit and its accessory subunit in vitro.

Authors:  T Tsurumi; T Daikoku; R Kurachi; Y Nishiyama
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

3.  Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.

Authors:  P Digard; K P Williams; P Hensley; I S Brooks; C E Dahl; D M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

4.  Determination and analysis of the complete nucleotide sequence of human herpesvirus.

Authors:  J Nicholas
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

5.  Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.

Authors:  E Cesarman; Y Chang; P S Moore; J W Said; D M Knowles
Journal:  N Engl J Med       Date:  1995-05-04       Impact factor: 91.245

6.  Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.

Authors:  Y Chang; E Cesarman; M S Pessin; F Lee; J Culpepper; D M Knowles; P S Moore
Journal:  Science       Date:  1994-12-16       Impact factor: 47.728

7.  Functional analysis of human cytomegalovirus polymerase accessory protein.

Authors:  K L Weiland; N L Oien; F Homa; M W Wathen
Journal:  Virus Res       Date:  1994-12       Impact factor: 3.303

8.  Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations.

Authors:  J S Lai; W Herr
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

9.  Cytomegalovirus-mediated induction of antisense mRNA expression to UL44 inhibits virus replication in an astrocytoma cell line: identification of an essential gene.

Authors:  A Ripalti; M C Boccuni; F Campanini; M P Landini
Journal:  J Virol       Date:  1995-04       Impact factor: 5.103

10.  Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease.

Authors:  J Soulier; L Grollet; E Oksenhendler; P Cacoub; D Cazals-Hatem; P Babinet; M F d'Agay; J P Clauvel; M Raphael; L Degos
Journal:  Blood       Date:  1995-08-15       Impact factor: 22.113
View more
  26 in total

1.  Identification and rapid quantification of early- and late-lytic human herpesvirus 8 infection in single cells by flow cytometric analysis: characterization of antiherpesvirus agents.

Authors:  J P Zoeteweij; S T Eyes; J M Orenstein; T Kawamura; L Wu; B Chandran; B Forghani; A Blauvelt
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

2.  Identification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approach.

Authors:  Janice Elaine Y Silverman; Mihai Ciustea; Abigail M Druck Shudofsky; Florent Bender; Robert H Shoemaker; Robert P Ricciardi
Journal:  Antiviral Res       Date:  2008-06-20       Impact factor: 5.970

3.  Downregulation of Poly(ADP-Ribose) Polymerase 1 by a Viral Processivity Factor Facilitates Lytic Replication of Gammaherpesvirus.

Authors:  Woo-Chang Chung; Joo-Hee Park; Hye-Ri Kang; Moon Jung Song
Journal:  J Virol       Date:  2015-07-08       Impact factor: 5.103

4.  The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.

Authors:  Jennifer L Baltz; David J Filman; Mihai Ciustea; Janice Elaine Y Silverman; Catherine L Lautenschlager; Donald M Coen; Robert P Ricciardi; James M Hogle
Journal:  J Virol       Date:  2009-09-16       Impact factor: 5.103

5.  A novel target and approach for identifying antivirals against molluscum contagiosum virus.

Authors:  Hancheng Guan; Manunya Nuth; Natalia Zhukovskaya; Yih Ling Saw; Edward Bell; Stuart N Isaacs; Robert P Ricciardi
Journal:  Antimicrob Agents Chemother       Date:  2014-09-29       Impact factor: 5.191

6.  Quantitative Analysis of the KSHV Transcriptome Following Primary Infection of Blood and Lymphatic Endothelial Cells.

Authors:  A Gregory Bruce; Serge Barcy; Terri DiMaio; Emilia Gan; H Jacques Garrigues; Michael Lagunoff; Timothy M Rose
Journal:  Pathogens       Date:  2017-03-19

7.  Kaposi's Sarcoma-Associated Herpesvirus Deregulates Host Cellular Replication during Lytic Reactivation by Disrupting the MCM Complex through ORF59.

Authors:  Roxanne Strahan; Prerna Dabral; Kammi Dingman; Christian Stadler; Kayla Hiura; Subhash C Verma
Journal:  J Virol       Date:  2018-10-29       Impact factor: 5.103

8.  Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element.

Authors:  Yunhua Liu; Yajun Cao; Deguang Liang; Yuan Gao; Tian Xia; Erle S Robertson; Ke Lan
Journal:  Virology       Date:  2008-09-10       Impact factor: 3.616

9.  Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLyt.

Authors:  Maria E McDowell; Pravinkumar Purushothaman; Cyprian C Rossetto; Gregory S Pari; Subhash C Verma
Journal:  J Virol       Date:  2013-05-15       Impact factor: 5.103

10.  The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques.

Authors:  A Gregory Bruce; Angela M Bakke; Courtney A Gravett; Laura K DeMaster; Helle Bielefeldt-Ohmann; Kellie L Burnside; Timothy M Rose
Journal:  Virol J       Date:  2009-11-18       Impact factor: 4.099
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.