Literature DB >> 9621066

Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2.

T Sakai1, Y Taniguchi, K Tamura, S Minoguchi, T Fukuhara, L J Strobl, U Zimber-Strobl, G W Bornkamm, T Honjo.   

Abstract

The intracellular region (RAMIC) of the mouse Notch1 receptor interacts with RBP-J/CBF-1, which binds to the DNA sequence CGTGGGAA and suppresses differentiation by transcriptional activation of genes regulated by RBP-J. Epstein-Barr virus nuclear antigen 2 (EBNA2) is essential for immortalization of human B cells by the virus. EBNA2 is a pleiotropic activator of viral and cellular genes and is targeted to DNA at least in part by interacting with RBP-J. We found that EBNA2 and the Notch1 RAMIC compete for binding to RBP-J, indicating that their interaction sites on RBP-J overlap at least partially. EBNA2 and Notch1 RAMIC transactivated the same set of viral and host promoters, i.e., the EBNA2 response element of the Epstein-Barr virus TP1 and the HES-1 promoter. Furthermore, EBNA2 functionally replaced the Notch1 RAMIC by suppressing differentiation of C2C12 myoblast progenitor cells.

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Year:  1998        PMID： 9621066      PMCID： PMC110408     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

1.  Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.

Authors:  J I Cohen; F Wang; J Mannick; E Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

2.  pEF-BOS, a powerful mammalian expression vector.

Authors:  S Mizushima; S Nagata
Journal:  Nucleic Acids Res       Date:  1990-09-11       Impact factor: 16.971

3.  A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif.

Authors:  N Matsunami; Y Hamaguchi; Y Yamamoto; K Kuze; K Kangawa; H Matsuo; M Kawaichi; T Honjo
Journal:  Nature       Date:  1989 Dec 21-28       Impact factor: 49.962

4.  The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein.

Authors:  S R Grossman; E Johannsen; X Tong; R Yalamanchili; E Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

5.  Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes.

Authors:  W Hammerschmidt; B Sugden
Journal:  Nature       Date:  1989-08-03       Impact factor: 49.962

6.  Recognition sequence of a highly conserved DNA binding protein RBP-J kappa.

Authors:  T Tun; Y Hamaguchi; N Matsunami; T Furukawa; T Honjo; M Kawaichi
Journal:  Nucleic Acids Res       Date:  1994-03-25       Impact factor: 16.971

7.  Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa.

Authors:  T Henkel; P D Ling; S D Hayward; M G Peterson
Journal:  Science       Date:  1994-07-01       Impact factor: 47.728

8.  TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

Authors:  L W Ellisen; J Bird; D C West; A L Soreng; T C Reynolds; S D Smith; J Sklar
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

9.  The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter.

Authors:  U Zimber-Strobl; E Kremmer; F Grässer; G Marschall; G Laux; G W Bornkamm
Journal:  EMBO J       Date:  1993-01       Impact factor: 11.598

10.  Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.

Authors:  H Kato; Y Taniguchi; H Kurooka; S Minoguchi; T Sakai; S Nomura-Okazaki; K Tamura; T Honjo
Journal:  Development       Date:  1997-10       Impact factor: 6.868
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  30 in total

1.  A role for SKIP in EBNA2 activation of CBF1-repressed promoters.

Authors:  S Zhou; M Fujimuro; J J Hsieh; L Chen; S D Hayward
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

2.  Intracellular forms of human NOTCH1 functionally activate essential Epstein-Barr virus major latent promoters in the Burkitt's lymphoma BJAB cell line but repress these promoters in Jurkat cells.

Authors:  M Cotter; J Callahan; J Aster; E Robertson
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

3.  Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex.

Authors:  S Zhou; S D Hayward
Journal:  Mol Cell Biol       Date:  2001-09       Impact factor: 4.272

Review 4.  The expression and function of Epstein-Barr virus encoded latent genes.

Authors:  L S Young; C W Dawson; A G Eliopoulos
Journal:  Mol Pathol       Date:  2000-10

5.  Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis.

Authors:  Jae Myun Lee; Kyoung-Ho Lee; Magdalena Weidner; Barbara A Osborne; S Diane Hayward
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-23       Impact factor: 11.205

6.  Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA.

Authors:  Rhett A Kovall; Wayne A Hendrickson
Journal:  EMBO J       Date:  2004-08-05       Impact factor: 11.598

7.  EBNA2 amino acids 3 to 30 are required for induction of LMP-1 and immortalization maintenance.

Authors:  Alexey V Gordadze; Chisaroka W Onunwor; RongSheng Peng; David Poston; Elisabeth Kremmer; Paul D Ling
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

8.  Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathway.

Authors:  Ke Lan; Daniel A Kuppers; Erle S Robertson
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

9.  The Epstein-Barr virus EBNA-LP protein preferentially coactivates EBNA2-mediated stimulation of latent membrane proteins expressed from the viral divergent promoter.

Authors:  Rongsheng Peng; Stephanie C Moses; Jie Tan; Elisabeth Kremmer; Paul D Ling
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

10.  A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent.

Authors:  Sabine Maier; Maja Santak; Anja Mantik; Kristina Grabusic; Elisabeth Kremmer; Wolfgang Hammerschmidt; Bettina Kempkes
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103
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