Literature DB >> 11091847

The expression and function of Epstein-Barr virus encoded latent genes.

L S Young1, C W Dawson, A G Eliopoulos.   

Abstract

The association of Epstein-Barr virus (EBV) with various malignancies is well established but the pattern of EBV latent gene expression in these different tumours is variable, reflecting distinct aspects of the virus-cell interaction. These different forms of EBV latency are associated with phenotypic variation and highlight the influence of EBV latent proteins on cell growth and survival. The EBV latent proteins have distinct functions associated with the maintenance of EBV infection and the control of various signalling and transcriptional pathways that facilitate the proliferation and survival of infected cells. Understanding the function of these EBV latent proteins will not only provide insight into the mechanisms governing fundamental cell processes but will also identify targets for novel treatment.

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Mesh：

Year:  2000        PMID： 11091847      PMCID： PMC1186976          DOI： 10.1136/mp.53.5.238

Source DB:  PubMed          Journal:  Mol Pathol        ISSN： 1366-8714


  115 in total

1.  Detection of Epstein-Barr virus in invasive breast cancers.

Authors:  M Bonnet; J M Guinebretiere; E Kremmer; V Grunewald; E Benhamou; G Contesso; I Joab
Journal:  J Natl Cancer Inst       Date:  1999-08-18       Impact factor: 13.506

2.  Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2.

Authors:  L J Strobl; H Höfelmayr; G Marschall; M Brielmeier; G W Bornkamm; U Zimber-Strobl
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

3.  The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.

Authors:  M Ikeda; A Ikeda; L C Longan; R Longnecker
Journal:  Virology       Date:  2000-03-01       Impact factor: 3.616

4.  Epstein-Barr virus (EBV) genes expression in cervical intraepithelial neoplasia and invasive cervical cancer: a comparative study with human papillomavirus (HPV) infection.

Authors:  T Sasagawa; M Shimakage; M Nakamura; J Sakaike; H Ishikawa; M Inoue
Journal:  Hum Pathol       Date:  2000-03       Impact factor: 3.466

5.  Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors.

Authors:  S Jayachandra; K G Low; A E Thlick; J Yu; P D Ling; Y Chang; P S Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

6.  An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation.

Authors:  K M Kaye; K M Izumi; H Li; E Johannsen; D Davidson; R Longnecker; E Kieff
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

Review 7.  Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?

Authors:  R Longnecker
Journal:  Adv Cancer Res       Date:  2000       Impact factor: 6.242

8.  Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses.

Authors:  J Uchida; T Yasui; Y Takaoka-Shichijo; M Muraoka; W Kulwichit; N Raab-Traub; H Kikutani
Journal:  Science       Date:  1999-10-08       Impact factor: 47.728

9.  Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription.

Authors:  S A Radkov; R Touitou; A Brehm; M Rowe; M West; T Kouzarides; M J Allday
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

10.  Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(alpha) and IL-1, and by the Epstein-Barr virus transforming protein LMP1.

Authors:  A Puls; A G Eliopoulos; C D Nobes; T Bridges; L S Young; A Hall
Journal:  J Cell Sci       Date:  1999-09       Impact factor: 5.285
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  28 in total

1.  Themed issue: the biology and pathology of the Epstein-Barr virus.

Authors:  P G Murray; L S Young
Journal:  Mol Pathol       Date:  2000-10

2.  Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-κB activation.

Authors:  Ciaren Graham; Hittu Matta; Yanqiang Yang; Han Yi; Yulan Suo; Bhairavi Tolani; Preet M Chaudhary
Journal:  J Virol       Date:  2012-12-12       Impact factor: 5.103

Review 3.  Phylogenetic comparison of Epstein-Barr virus genomes.

Authors:  Su Jin Choi; Seok Won Jung; Sora Huh; Hyosun Cho; Hyojeung Kang
Journal:  J Microbiol       Date:  2018-06-14       Impact factor: 3.422

Review 4.  Stable intronic sequence RNAs (sisRNAs): a new layer of gene regulation.

Authors:  Ismail Osman; Mandy Li-Ian Tay; Jun Wei Pek
Journal:  Cell Mol Life Sci       Date:  2016-05-04       Impact factor: 9.261

5.  A new model of LMP1-MYC interaction in B cell lymphoma.

Authors:  Evelena P Ontiveros; Ahmad Halwani; Laura L Stunz; Natalie Kamberos; Alicia K Olivier; Siegfried Janz; Gail A Bishop
Journal:  Leuk Lymphoma       Date:  2014-04-23

6.  CD19 signalling improves the Epstein-Barr virus-induced immortalization of human B cell.

Authors:  D Y Hur; M H Lee; J W Kim; J-H Kim; Y K Shin; J K Rho; K B Kwack; W J Lee; B G Han
Journal:  Cell Prolif       Date:  2005-02       Impact factor: 6.831

7.  EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis.

Authors:  Ting-Yun Liu; Shang-Ju Wu; Mi-Hsin Huang; Fei-Yun Lo; Mong-Hsun Tsai; Ching-Hwa Tsai; Su-Ming Hsu; Chung-Wu Lin
Journal:  Mol Cancer       Date:  2010-02-09       Impact factor: 27.401

8.  Identification of a negative regulatory element in the Epstein-Barr virus Zta transactivation domain that is regulated by the cell cycle control factors c-Myc and E2F1.

Authors:  Zhen Lin; Qinyan Yin; Erik Flemington
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

9.  Molecular basis of cytotoxicity of Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) in EBV latency III B cells: LMP1 induces type II ligand-independent autoactivation of CD95/Fas with caspase 8-mediated apoptosis.

Authors:  Christophe Le Clorennec; Tan-Sothéa Ouk; Ibtissam Youlyouz-Marfak; Stéphanie Panteix; Catherine-Claude Martin; Julia Rastelli; Eric Adriaenssens; Ursula Zimber-Strobl; Jean Coll; Jean Feuillard; Chantal Jayat-Vignoles
Journal:  J Virol       Date:  2008-04-30       Impact factor: 5.103

10.  Epstein-Barr virus latent nuclear antigens can induce metastasis in a nude mouse model.

Authors:  Rajeev Kaul; Masanao Murakami; Tathagata Choudhuri; Erle S Robertson
Journal:  J Virol       Date:  2007-07-18       Impact factor: 5.103
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