Literature DB >> 9618496

The gastrulation defective gene of Drosophila melanogaster is a member of the serine protease superfamily.

K D Konrad1, T J Goralski, A P Mahowald, J L Marsh.   

Abstract

The establishment of dorsal-ventral polarity in the oocyte involves two sets of genes. One set belongs to the gurken-torpedo signaling pathway and affects the development of the egg chorion as well as the polarity of the embryo. The second set of genes affects only the dorsal-ventral polarity of the embryo but not the eggshell. gastrulation defective is one of the earliest acting of this second set of maternally required genes. We have cloned and characterized the gastrulation defective gene and determined that it encodes a protein structurally related to the serine protease superfamily, which also includes the Snake, Easter, and Nudel proteins. These data provide additional support for the involvement of a protease cascade in generating an asymmetric signal (i.e., asymmetric Spätzle activity) during establishment of dorsal-ventral polarity in the Drosophila embryo.

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Year:  1998        PMID： 9618496      PMCID： PMC22648          DOI： 10.1073/pnas.95.12.6819

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  43 in total

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Journal:  Annu Rev Genet       Date:  1995       Impact factor: 16.830

2.  windbeutel, a gene required for dorsoventral patterning in Drosophila, encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum.

Authors:  M Konsolaki; T Schüpbach
Journal:  Genes Dev       Date:  1998-01-01       Impact factor: 11.361

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Journal:  Cell       Date:  1989-02-10       Impact factor: 41.582

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Authors:  C Hashimoto; K L Hudson; K V Anderson
Journal:  Cell       Date:  1988-01-29       Impact factor: 41.582

5.  Transposition of cloned P elements into Drosophila germ line chromosomes.

Authors:  A C Spradling; G M Rubin
Journal:  Science       Date:  1982-10-22       Impact factor: 47.728

6.  Complete primary structure for the zymogen of human complement factor B.

Authors:  J E Mole; J K Anderson; E A Davison; D E Woods
Journal:  J Biol Chem       Date:  1984-03-25       Impact factor: 5.157

7.  A simple method for displaying the hydropathic character of a protein.

Authors:  J Kyte; R F Doolittle
Journal:  J Mol Biol       Date:  1982-05-05       Impact factor: 5.469

8.  Behavioral and cytogenetic analysis of the cacophony courtship song mutant and interacting genetic variants in Drosophila melanogaster.

Authors:  S J Kulkarni; J C Hall
Journal:  Genetics       Date:  1987-03       Impact factor: 4.562

9.  Crystal structure analysis and refinement of two variants of trigonal trypsinogen: trigonal trypsin and PEG (polyethylene glycol) trypsinogen and their comparison with orthorhombic trypsin and trigonal trypsinogen.

Authors:  W Bode; R Huber
Journal:  FEBS Lett       Date:  1978-06-15       Impact factor: 4.124

10.  Developmental genetics of the gastrulation defective locus in Drosophila melanogaster.

Authors:  K D Konrad; T J Goralski; A P Mahowald
Journal:  Dev Biol       Date:  1988-05       Impact factor: 3.582
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  17 in total

1.  Activation of a protease cascade involved in patterning the Drosophila embryo.

Authors:  E K LeMosy; Y Q Tan; C Hashimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

2.  Interallelic complementation at the Drosophila melanogaster gastrulation defective locus defines discrete functional domains of the protein.

Authors:  G Ponomareff; H Giordano; Y DeLotto; R DeLotto
Journal:  Genetics       Date:  2001-10       Impact factor: 4.562

3.  Autoproteolysis and feedback in a protease cascade directing Drosophila dorsal-ventral cell fate.

Authors:  M Dissing; H Giordano; R DeLotto
Journal:  EMBO J       Date:  2001-05-15       Impact factor: 11.598

4.  Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe.

Authors:  Zhenyu Zhang; Xianjun Zhu; Leslie M Stevens; David Stein
Journal:  Development       Date:  2009-08       Impact factor: 6.868

5.  A Developmental Program Truncates Long Transcripts to Temporally Regulate Cell Signaling.

Authors:  Jeremy E Sandler; Jihyun Irizarry; Vincent Stepanik; Leslie Dunipace; Henry Amrhein; Angelike Stathopoulos
Journal:  Dev Cell       Date:  2018-12-17       Impact factor: 12.270

Review 6.  Maternal control of the Drosophila dorsal-ventral body axis.

Authors:  David S Stein; Leslie M Stevens
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2014-05-29       Impact factor: 5.814

7.  Comparative genomics of the eukaryotes.

Authors:  G M Rubin; M D Yandell; J R Wortman; G L Gabor Miklos; C R Nelson; I K Hariharan; M E Fortini; P W Li; R Apweiler; W Fleischmann; J M Cherry; S Henikoff; M P Skupski; S Misra; M Ashburner; E Birney; M S Boguski; T Brody; P Brokstein; S E Celniker; S A Chervitz; D Coates; A Cravchik; A Gabrielian; R F Galle; W M Gelbart; R A George; L S Goldstein; F Gong; P Guan; N L Harris; B A Hay; R A Hoskins; J Li; Z Li; R O Hynes; S J Jones; P M Kuehl; B Lemaitre; J T Littleton; D K Morrison; C Mungall; P H O'Farrell; O K Pickeral; C Shue; L B Vosshall; J Zhang; Q Zhao; X H Zheng; S Lewis
Journal:  Science       Date:  2000-03-24       Impact factor: 47.728

8.  Ovochymase, a Xenopus laevis egg extracellular protease, is translated as part of an unusual polyprotease.

Authors:  L L Lindsay; J C Yang; J L Hedrick
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

9.  Gastrulation defective, a complement factor C2/B-like protease, interprets a ventral prepattern in Drosophila.

Authors:  R DeLotto
Journal:  EMBO Rep       Date:  2001-08       Impact factor: 8.807

10.  Gastrulation defective is a serine protease involved in activating the receptor toll to polarize the Drosophila embryo.

Authors:  J H Han; S H Lee; Y Q Tan; E K LeMosy; C Hashimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205
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