Literature DB >> 9609828

Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans.

W G Kelly1, A Fire.   

Abstract

The germline of the nematode Caenorhabditis elegans exhibits a remarkable ability to specifically silence transgenic DNA. We have shown that this silencing mechanism is disrupted in animals mutant for the maternal effect sterile genes mes-2, mes-3, mes-4 and mes-6. The proteins encoded by mes-2 and mes-6 have been shown to be related to the Polycomb Group of transcriptional repressors (Holdeman, R., Nehrt, S. and Strome, S. (1998). Development 125, 2457-2467; Korf, I., Fan, F. and Strome, S. (1998). Development 125, 2469-2478). These results suggest that a genetic silencing process is essential for sustained germline function, and that this silencing is mediated, at least in part, by Polycomb Group proteins.

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Year:  1998        PMID： 9609828      PMCID： PMC4084878          DOI： 10.1242/dev.125.13.2451

Source DB:  PubMed          Journal:  Development        ISSN： 0950-1991            Impact factor:   6.868


  28 in total

Review 1.  The vagaries of variegating transgenes.

Authors:  D I Martin; E Whitelaw
Journal:  Bioessays       Date:  1996-11       Impact factor: 4.345

2.  Genes that implement the hermaphrodite mode of dosage compensation in Caenorhabditis elegans.

Authors:  J D Plenefisch; L DeLong; B J Meyer
Journal:  Genetics       Date:  1989-01       Impact factor: 4.562

Review 3.  The dichotomy between germ line and somatic line, and the origin of cell mortality.

Authors:  H Denis; J C Lacroix
Journal:  Trends Genet       Date:  1993-01       Impact factor: 11.639

Review 4.  Chromatin domains as potential units of eukaryotic gene function.

Authors:  N Dillon; F Grosveld
Journal:  Curr Opin Genet Dev       Date:  1994-04       Impact factor: 5.578

5.  High-frequency excision of transposable element Tc 1 in the nematode Caenorhabditis elegans is limited to somatic cells.

Authors:  S W Emmons; L Yesner
Journal:  Cell       Date:  1984-03       Impact factor: 41.582

6.  The embryonic cell lineage of the nematode Caenorhabditis elegans.

Authors:  J E Sulston; E Schierenberg; J G White; J N Thomson
Journal:  Dev Biol       Date:  1983-11       Impact factor: 3.582

7.  Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent.

Authors:  M Pal-Bhadra; U Bhadra; J A Birchler
Journal:  Cell       Date:  1997-08-08       Impact factor: 41.582

8.  The genetics of Caenorhabditis elegans.

Authors:  S Brenner
Journal:  Genetics       Date:  1974-05       Impact factor: 4.562

9.  Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans.

Authors:  P G Okkema; S W Harrison; V Plunger; A Aryana; A Fire
Journal:  Genetics       Date:  1993-10       Impact factor: 4.562

10.  The Polycomb group in Caenorhabditis elegans and maternal control of germline development.

Authors:  I Korf; Y Fan; S Strome
Journal:  Development       Date:  1998-07       Impact factor: 6.868
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  103 in total

1.  Mutations in the FIE and MEA genes that encode interacting polycomb proteins cause parent-of-origin effects on seed development by distinct mechanisms.

Authors:  R Yadegari; T Kinoshita; O Lotan; G Cohen; A Katz; Y Choi; A Katz; K Nakashima; J J Harada; R B Goldberg; R L Fischer; N Ohad
Journal:  Plant Cell       Date:  2000-12       Impact factor: 11.277

Review 2.  The rest is silence.

Authors:  E Bernstein; A M Denli; G J Hannon
Journal:  RNA       Date:  2001-11       Impact factor: 4.942

3.  A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development.

Authors:  Florence Couteau; Frederic Guerry; Fritz Muller; Francesca Palladino
Journal:  EMBO Rep       Date:  2002-02-15       Impact factor: 8.807

4.  A C. elegans eIF4E-family member upregulates translation at elevated temperatures of mRNAs encoding MSH-5 and other meiotic crossover proteins.

Authors:  Anren Song; Sara Labella; Nadejda L Korneeva; Brett D Keiper; Eric J Aamodt; Monique Zetka; Robert E Rhoads
Journal:  J Cell Sci       Date:  2010-06-08       Impact factor: 5.285

5.  A Drosophila chromatin factor interacts with the Piwi-interacting RNA mechanism in niche cells to regulate germline stem cell self-renewal.

Authors:  Tora K Smulders-Srinivasan; Akos Szakmary; Haifan Lin
Journal:  Genetics       Date:  2010-07-20       Impact factor: 4.562

Review 6.  Cancer models in Caenorhabditis elegans.

Authors:  Natalia V Kirienko; Kumaran Mani; David S Fay
Journal:  Dev Dyn       Date:  2010-05       Impact factor: 3.780

7.  Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.

Authors:  Willy M Baarends; Evelyne Wassenaar; Roald van der Laan; Jos Hoogerbrugge; Esther Sleddens-Linkels; Jan H J Hoeijmakers; Peter de Boer; J Anton Grootegoed
Journal:  Mol Cell Biol       Date:  2005-02       Impact factor: 4.272

8.  Transcriptional silencing of a transgene by RNAi in the soma of C. elegans.

Authors:  Alla Grishok; Jina L Sinskey; Phillip A Sharp
Journal:  Genes Dev       Date:  2005-03-01       Impact factor: 11.361

9.  The C.elegans MAPK phosphatase LIP-1 is required for the G(2)/M meiotic arrest of developing oocytes.

Authors:  Alex Hajnal; Thomas Berset
Journal:  EMBO J       Date:  2002-08-15       Impact factor: 11.598

10.  Characterizing the transcriptional regulation of let-721, a Caenorhabditis elegans homolog of human electron flavoprotein dehydrogenase.

Authors:  Derek S Chew; Allan K Mah; David L Baillie
Journal:  Mol Genet Genomics       Date:  2009-09-23       Impact factor: 3.291
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