Literature DB >> 9607316

Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions.

T M Millar1, C R Stevens, N Benjamin, R Eisenthal, R Harrison, D R Blake.   

Abstract

Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Generation of nitric oxide is not detectable under normoxic conditions and is inhibited by the molybdenum site-specific inhibitors, oxypurinol and (-)BOF 4272. These enzymic reactions provide a mechanism for generation of NO under hypoxic conditions where nitric oxide synthase does not function, suggesting a vasodilatory role in ischaemia.

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Year:  1998        PMID： 9607316     DOI： 10.1016/s0014-5793(98)00430-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  134 in total

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Review 4.  After 130 years, the molecular mechanism of action of nitroglycerin is revealed.

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5.  Antimicrobial properties of milk: dependence on presence of xanthine oxidase and nitrite.

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7.  Various intracellular compartments cooperate in the release of nitric oxide from glycerol trinitrate in liver.

Authors:  Andrey V Kozlov; Barbara Dietrich; Hans Nohl
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8.  Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase.

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Journal:  Circ Res       Date:  2008-09-25       Impact factor: 17.367

Review 9.  Xanthine oxidoreductase-catalyzed reduction of nitrite to nitric oxide: insights regarding where, when and how.

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10.  The antimicrobial activity of bovine milk xanthine oxidase.

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Journal:  Int Dairy J       Date:  2019-10-31       Impact factor: 3.032
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