Literature DB >> 12060725

After 130 years, the molecular mechanism of action of nitroglycerin is revealed.

Louis J Ignarro1.   

Abstract

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Year:  2002        PMID： 12060725      PMCID： PMC122975          DOI： 10.1073/pnas.132271799

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  21 in total

1.  Nitroglycerin tolerance in human vessels: evidence for impaired nitroglycerin bioconversion.

Authors:  P R Sage; I S de la Lande; I Stafford; C L Bennett; G Phillipov; J Stubberfield; J D Horowitz
Journal:  Circulation       Date:  2000-12-05       Impact factor: 29.690

2.  Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions.

Authors:  T M Millar; C R Stevens; N Benjamin; R Eisenthal; R Harrison; D R Blake
Journal:  FEBS Lett       Date:  1998-05-08       Impact factor: 4.124

3.  Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations.

Authors:  W P Arnold; C K Mittal; S Katsuki; F Murad
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

4.  Mechanism of tolerance development to organic nitrates.

Authors:  P Needleman; E M Johnson
Journal:  J Pharmacol Exp Ther       Date:  1973-03       Impact factor: 4.030

Review 5.  Organic nitrate metabolism.

Authors:  P Needleman
Journal:  Annu Rev Pharmacol Toxicol       Date:  1976       Impact factor: 13.820

6.  Sulfhydryl requirement for relaxation of vascular smooth muscle.

Authors:  P Needleman; B Jakschik; E M Johnson
Journal:  J Pharmacol Exp Ther       Date:  1973-11       Impact factor: 4.030

7.  Identification of the enzymatic mechanism of nitroglycerin bioactivation.

Authors:  Zhiqiang Chen; Jian Zhang; Jonathan S Stamler
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-04       Impact factor: 11.205

8.  Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels.

Authors:  S Boesgaard; J Aldershvile; H E Poulsen; S Loft; M E Anderson; A Meister
Journal:  Circ Res       Date:  1994-01       Impact factor: 17.367

9.  Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate.

Authors:  J J McGuire; D J Anderson; B J McDonald; R Narayanasami; B M Bennett
Journal:  Biochem Pharmacol       Date:  1998-10-01       Impact factor: 5.858

10.  Inactivation of human aldehyde dehydrogenase by isosorbide dinitrate.

Authors:  N Mukerjee; R Pietruszko
Journal:  J Biol Chem       Date:  1994-08-26       Impact factor: 5.157
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  21 in total

Review 1.  Nitroglycerin use in myocardial infarction patients.

Authors:  Julio C B Ferreira; Daria Mochly-Rosen
Journal:  Circ J       Date:  2011-11-01       Impact factor: 2.993

2.  Daily low-dose folic acid supplementation does not prevent nitroglycerin-induced nitric oxide synthase dysfunction and tolerance: a human in vivo study.

Authors:  Jonathan M DiFabio; Tommaso Gori; George Thomas; Sean Jedrzkiewicz; John D Parker
Journal:  Can J Cardiol       Date:  2010-11       Impact factor: 5.223

Review 3.  Recent developments in nitric oxide donor drugs.

Authors:  M R Miller; I L Megson
Journal:  Br J Pharmacol       Date:  2007-04-02       Impact factor: 8.739

4.  Sex differences in cardiovascular drug-induced adverse reactions causing hospital admissions.

Authors:  Eline M Rodenburg; Bruno H Stricker; Loes E Visser
Journal:  Br J Clin Pharmacol       Date:  2012-12       Impact factor: 4.335

5.  Acute Heart Failure Treatment.

Authors:  Phillip D Levy; Abdel Bellou
Journal:  Curr Emerg Hosp Med Rep       Date:  2013-06-01

6.  Vasodilators in Acute Heart Failure: Review of the Latest Studies.

Authors:  Phillip D Levy; Said Laribi; Alexandre Mebazaa
Journal:  Curr Emerg Hosp Med Rep       Date:  2014-06

7.  Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension.

Authors:  Suênia K P Porpino; Christa Zollbrecht; Maria Peleli; Marcelo F Montenegro; Maria C R Brandão; Petrônio F Athayde-Filho; Maria S França-Silva; Erik Larsson; Jon O Lundberg; Eddie Weitzberg; Erik G Persson; Valdir A Braga; Mattias Carlström
Journal:  Br J Pharmacol       Date:  2016-06-12       Impact factor: 8.739

8.  An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.

Authors:  Zhiqiang Chen; Matthew W Foster; Jian Zhang; Lan Mao; Howard A Rockman; Toshihiro Kawamoto; Kyoko Kitagawa; Keiichi I Nakayama; Douglas T Hess; Jonathan S Stamler
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-15       Impact factor: 11.205

9.  Serum myeloperoxidase levels independently predict endothelial dysfunction in humans.

Authors:  Joseph A Vita; Marie-Luise Brennan; Noyan Gokce; Shirley A Mann; Marlene Goormastic; Mehdi H Shishehbor; Marc S Penn; John F Keaney; Stanley L Hazen
Journal:  Circulation       Date:  2004-08-23       Impact factor: 29.690

10.  Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin.

Authors:  Matteo Beretta; Astrid Sottler; Kurt Schmidt; Bernd Mayer; Antonius C F Gorren
Journal:  J Biol Chem       Date:  2008-09-11       Impact factor: 5.157
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