Literature DB >> 9602505

A fifth human cytomegalovirus glycoprotein B genotype.

D H Shepp1, M E Match, S M Lipson, R G Pergolizzi.   

Abstract

Genetic variation in glycoprotein B (gB) may play a role in human cytomegalovirus (HCMV) pathogenesis. Using restriction endonuclease digestion and DNA sequencing, a unique gB genotype was identified in eight HCMV strains isolated from five patients with the acquired immune deficiency syndrome. Nucleic acid homology to the four previously described gB genotypes ranged from 79 to 91% for the two major variable regions of gB. Studies of the role of gB in HCMV pathogenesis should recognize the existence of live gB genotypes.

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Year:  1998        PMID： 9602505     DOI： 10.1016/s0923-2516(98)80086-1

Source DB:  PubMed          Journal:  Res Virol        ISSN： 0923-2516


  18 in total

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