Literature DB >> 9600119

Establishment of Epstein-Barr virus-positive human gastric epithelial cell lines.

M Tajima1, M Komuro, K Okinaga.   

Abstract

We have established two Epstein-Barr virus (EBV)-positive cell lines, GT38 and GT39, derived from human gastric tissues of two patients bearing gastric carcinoma. Both cell lines were positive for cytokeratin, an epithelial marker, but not for lymphocyte-related markers. Unlike GT39 cell line, GT38 cells lacked the property of contact inhibition. EBV genome was detected in both cell lines. The cell lines were positive for latent membrane protein 1, and EBV-determined nuclear antigen 1 (EBNA1). EBNA2 was also detected in GT38. These cell lines should be useful for studying the interaction of EBV with gastric epithelial cells and its role in gastric carcinogenesis.

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Year:  1998        PMID： 9600119      PMCID： PMC5921807          DOI： 10.1111/j.1349-7006.1998.tb00557.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  33 in total

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Journal:  Am J Pathol       Date:  1993-11       Impact factor: 4.307

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Authors:  Y Takano; Y Kato
Journal:  J Pathol       Date:  1995-01       Impact factor: 7.996

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Authors:  S T Yuen; L P Chung; S Y Leung; I S Luk; S Y Chan; J Ho
Journal:  Am J Surg Pathol       Date:  1994-11       Impact factor: 6.394

9.  Expression of the Epstein-Barr virus (EBV) latent membrane protein is tightly regulated, independently of EB nuclear antigen 2 and of EBV integration or copy number.

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Journal:  Virus Res       Date:  1993-01       Impact factor: 3.303

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Authors:  J Martin; B Sugden
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103
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  6 in total

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Authors:  Y Chang; C H Tung; Y T Huang; J Lu; J Y Chen; C H Tsai
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

2.  ZEB negatively regulates the lytic-switch BZLF1 gene promoter of Epstein-Barr virus.

Authors:  Richard J Kraus; Jacqueline G Perrigoue; Janet E Mertz
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

Review 3.  Epstein-Barr virus and gastric carcinoma.

Authors:  K Takada
Journal:  Mol Pathol       Date:  2000-10

4.  Differential effect of TPA on cell growth and Epstein-Barr virus reactivation in epithelial cell lines derived from gastric tissues and B cell line Raji.

Authors:  M Kanamori; M Tajima; Y Satoh; Y Hoshikawa; Y Miyazawa; K Okinaga; T Kurata; T Sairenji
Journal:  Virus Genes       Date:  2000       Impact factor: 2.332

5.  Macaque homologs of Kaposi's sarcoma-associated herpesvirus (KSHV) infect germinal center lymphoid cells, epithelial cells in skin and gastrointestinal tract and gonadal germ cells in naturally infected macaques.

Authors:  Helle Bielefeldt-Ohmann; A Gregory Bruce; Kellie Howard; Minako Ikoma; Margaret E Thouless; Timothy M Rose
Journal:  Virology       Date:  2018-04-22       Impact factor: 3.616

6.  Inhibition of Epstein-Barr virus (EBV) reactivation by short interfering RNAs targeting p38 mitogen-activated protein kinase or c-myc in EBV-positive epithelial cells.

Authors:  Xiangrong Gao; Haoran Wang; Takeshi Sairenji
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103
  6 in total

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