Literature DB >> 959825

Photochemotherapy: identification of a metabolite of 4, 5', 8-trimethylpsoralen.

B B Mandula, M A Pathak, G Dudek.   

Abstract

A compound, 4, 8-dimethyl, 5'-carboxypsoralen (DMeCP), has been identified in mouse urine as a major metabolite of the photoactive drug, 4, 5', 8-trimethylpsoralen (TMeP). This drug is widely used in the treatment of vitiligo and psoriasis. DMeCP is fluorescent, and nonphotosensitizing when tested on guinea pig skin. DMeCP also occurs in the urine of human patients receiving TMeP orally.

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Year:  1976        PMID： 959825     DOI： 10.1126/science.959825

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

Review 1.  Determination of 8-methoxypsoralen in serum, aqueous, and lens: relation to long-wave ultraviolet phototoxicity in experimental and clinical photochemotherapy.

Authors:  W B Glew
Journal:  Trans Am Ophthalmol Soc       Date:  1979

2.  DNA unwinding induced by photoaddition of psoralen derivatives and determination of dark-binding equilibrium constants by gel electrophoresis.

Authors:  G Wiesehahn; J E Hearst
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

3.  The metabolism of 8-methoxypsoralen in man.

Authors:  J Schmid; A Prox; A Reuter; H Zipp; F W Koss
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1980       Impact factor: 2.441

4.  The carcinogenic properties of topical PUVA. A lifelong study in mice.

Authors:  M Hannuksela; F Stenbäck; A Lahti
Journal:  Arch Dermatol Res       Date:  1986       Impact factor: 3.017
  4 in total

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