| Literature DB >> 9596583 |
M Kengaku1, J Capdevila, C Rodriguez-Esteban, J De La Peña, R L Johnson, J C Izpisúa Belmonte, C J Tabin.
Abstract
The apical ectodermal ridge (AER) is an essential structure for vertebrate limb development. Wnt3a is expressed during the induction of the chick AER, and misexpression of Wnt3a induces ectopic expression of AER-specific genes in the limb ectoderm. The genes beta-catenin and Lef1 can mimic the effect of Wnt3a, and blocking the intrinsic Lef1 activity disrupts AER formation. Hence, Wnt3a functions in AER formation through the beta-catenin/LEF1 pathway. In contrast, neither beta-catenin nor Lef1 affects the Wnt7a-regulated dorsoventral polarity of the limb. Thus, two related Wnt genes elicit distinct responses in the same tissues by using different intracellular pathways.Entities:
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Year: 1998 PMID： 9596583 DOI： 10.1126/science.280.5367.1274
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728