Literature DB >> 12923052

Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.

Natalia Soshnikova1, Dietmar Zechner, Joerg Huelsken, Yuji Mishina, Richard R Behringer, Makoto M Taketo, E Bryan Crenshaw, Walter Birchmeier.   

Abstract

By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling.

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Year:  2003        PMID： 12923052      PMCID： PMC196251          DOI： 10.1101/gad.263003

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  33 in total

Review 1.  Wnt signaling and cancer.

Authors:  P Polakis
Journal:  Genes Dev       Date:  2000-08-01       Impact factor: 11.361

2.  Regulatory regions from the Brn4 promoter direct LACZ expression to the developing forebrain and neural tube.

Authors:  A Heydemann; L C Nguyen; E B Crenshaw
Journal:  Brain Res Dev Brain Res       Date:  2001-05-31

3.  Functional interaction of beta-catenin with the transcription factor LEF-1.

Authors:  J Behrens; J P von Kries; M Kühl; L Bruhn; D Wedlich; R Grosschedl; W Birchmeier
Journal:  Nature       Date:  1996-08-15       Impact factor: 49.962

4.  Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene.

Authors:  N Harada; Y Tamai; T Ishikawa; B Sauer; K Takaku; M Oshima; M M Taketo
Journal:  EMBO J       Date:  1999-11-01       Impact factor: 11.598

Review 5.  Regulation of LEF-1/TCF transcription factors by Wnt and other signals.

Authors:  Q Eastman; R Grosschedl
Journal:  Curr Opin Cell Biol       Date:  1999-04       Impact factor: 8.382

6.  beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.

Authors:  J Huelsken; R Vogel; B Erdmann; G Cotsarelis; W Birchmeier
Journal:  Cell       Date:  2001-05-18       Impact factor: 41.582

7.  WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo.

Authors:  Y Kawakami; J Capdevila; D Büscher; T Itoh; C Rodríguez Esteban; J C Izpisúa Belmonte
Journal:  Cell       Date:  2001-03-23       Impact factor: 41.582

8.  Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.

Authors:  K Kratochwil; M Dull; I Farinas; J Galceran; R Grosschedl
Journal:  Genes Dev       Date:  1996-06-01       Impact factor: 11.361

9.  The mouse Engrailed-1 gene and ventral limb patterning.

Authors:  C A Loomis; E Harris; J Michaud; W Wurst; M Hanks; A L Joyner
Journal:  Nature       Date:  1996-07-25       Impact factor: 49.962

10.  The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.

Authors:  P H Crossley; G R Martin
Journal:  Development       Date:  1995-02       Impact factor: 6.868
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  60 in total

1.  The E6 oncoprotein from HPV16 enhances the canonical Wnt/β-catenin pathway in skin epidermis in vivo.

Authors:  José Bonilla-Delgado; Gülay Bulut; Xuefeng Liu; Enoc M Cortés-Malagón; Richard Schlegel; Catalina Flores-Maldonado; Rubén G Contreras; Sang-Hyuk Chung; Paul F Lambert; Aykut Uren; Patricio Gariglio
Journal:  Mol Cancer Res       Date:  2011-12-07       Impact factor: 5.852

2.  A transgenic, mesodermal specific, Dkk1 mouse model recapitulates a spectrum of human congenital limb reduction defects.

Authors:  Filemon Dela Cruz; Melissa Terry; Igor Matushansky
Journal:  Differentiation       Date:  2012-03-08       Impact factor: 3.880

Review 3.  A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.

Authors:  Kevin A Maupin; Casey J Droscha; Bart O Williams
Journal:  Bone Res       Date:  2013-03-29       Impact factor: 13.567

4.  Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation.

Authors:  Bo Liu; Hsiao-Man Ivy Yu; Wei Hsu
Journal:  Dev Biol       Date:  2006-10-21       Impact factor: 3.582

5.  BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.

Authors:  Irina B Grishina; Sung Yup Kim; Christopher Ferrara; Helen P Makarenkova; Paul D Walden
Journal:  Dev Biol       Date:  2005-12-15       Impact factor: 3.582

6.  β-Catenin is essential for Müllerian duct regression during male sexual differentiation.

Authors:  Akio Kobayashi; C Allison Stewart; Ying Wang; Kaoru Fujioka; Nicholas C Thomas; Soazik P Jamin; Richard R Behringer
Journal:  Development       Date:  2011-04-13       Impact factor: 6.868

7.  Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.

Authors:  Alexandra Klaus; Yumiko Saga; Makoto M Taketo; Eldad Tzahor; Walter Birchmeier
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-13       Impact factor: 11.205

8.  Wnt-mediated self-renewal of neural stem/progenitor cells.

Authors:  M Yashar S Kalani; Samuel H Cheshier; Branden J Cord; Simon R Bababeygy; Hannes Vogel; Irving L Weissman; Theo D Palmer; Roel Nusse
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-28       Impact factor: 11.205

Review 9.  Adhesive and signaling functions of cadherins and catenins in vertebrate development.

Authors:  Ewa Stepniak; Glenn L Radice; Valeri Vasioukhin
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-11       Impact factor: 10.005

10.  Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program.

Authors:  Shinichi Miyagawa; Anne Moon; Ryuma Haraguchi; Chie Inoue; Masayo Harada; Chiaki Nakahara; Kentaro Suzuki; Daisuke Matsumaru; Takehito Kaneko; Isao Matsuo; Lei Yang; Makoto M Taketo; Taisen Iguchi; Sylvia M Evans; Gen Yamada
Journal:  Development       Date:  2009-12       Impact factor: 6.868
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