Literature DB >> 959566

Defective PGE reactivity in leucocytes of multiple sclerosis patients.

P J Kirby, J Morley, J R Ponsford, W I McDonald.   

Abstract

Leucocyte migration inhibition in vitro, in response to antigen or mitogen, is suppressed by PGE2 (0.01-1.0 mug/ml). The susceptibility of leucocytes to such inhibition by PGE2 has been compared using cell preparations obtained from normal individuals, multiple sclerosis patients and from patients with other neurological diseases. The results indicate defective reactivity of leucocytes from multiple sclerosis patients.

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Year:  1976        PMID: 959566     DOI: 10.1016/0090-6980(76)90065-4

Source DB:  PubMed          Journal:  Prostaglandins        ISSN: 0090-6980


  6 in total

Review 1.  The role of prostaglandins in altered leukocyte function in multiple sclerosis.

Authors:  P Dore-Duffy; S Y Ho; M Longo
Journal:  Springer Semin Immunopathol       Date:  1985

2.  Prostaglandins and the lung.

Authors:  J Morley
Journal:  Postgrad Med J       Date:  1977-11       Impact factor: 2.401

3.  Prostaglandin-mediated inhibition of lymphokine secretion in normal individuals and patients with progressive systemic sclerosis (scleroderma, PSS).

Authors:  R H Kelly; D H Miller; G P Rodnan; J Hagmann
Journal:  Agents Actions       Date:  1982-10

Review 4.  Regulation of the immune response by prostaglandins.

Authors:  J S Goodwin; J Ceuppens
Journal:  J Clin Immunol       Date:  1983-10       Impact factor: 8.317

5.  Influence of prostaglandin E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple sclerosis patients and healthy donors.

Authors:  G Vervliet; H Deckmyn; H Carton; A Billiau
Journal:  J Clin Immunol       Date:  1985-03       Impact factor: 8.317

Review 6.  Regulation of allergic responses by prostaglandins: a review.

Authors:  J Morley; J L Beets; M A Bray; W Paul
Journal:  J R Soc Med       Date:  1980-06       Impact factor: 18.000

  6 in total

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