Literature DB >> 9593162

Sequence of the gene encoding a plasmid-mediated cefotaxime-hydrolyzing class A beta-lactamase (CTX-M-4): involvement of serine 237 in cephalosporin hydrolysis.

M Gazouli1, E Tzelepi, S V Sidorenko, L S Tzouvelekis.   

Abstract

The sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-4) was determined. It was located in a plasmid harbored by a Salmonella typhimurium strain. CTX-M-4 was similar to the plasmidic cefotaxime-hydrolyzing beta-lactamases CTX-M-2 and Toho-1 and related to the chromosomal beta-lactamase of Klebsiella oxytoca. A Ser-237-->Ala substitution, introduced by site-directed mutagenesis, caused minor alterations in the interaction of CTX-M-4 with beta-lactams, reducing slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate.

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Year:  1998        PMID： 9593162      PMCID： PMC105797          DOI： 10.1128/AAC.42.5.1259

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  A standard numbering scheme for the class A beta-lactamases.

Authors:  R P Ambler; A F Coulson; J M Frère; J M Ghuysen; B Joris; M Forsman; R C Levesque; G Tiraby; S G Waley
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

2.  Close amino acid sequence relationship between the new plasmid-mediated extended-spectrum beta-lactamase MEN-1 and chromosomally encoded enzymes of Klebsiella oxytoca.

Authors:  M Barthélémy; J Péduzzi; H Bernard; C Tancrède; R Labia
Journal:  Biochim Biophys Acta       Date:  1992-07-13

3.  A new plasmidic cefotaximase from patients infected with Salmonella typhimurium.

Authors:  A Bauernfeind; J M Casellas; M Goldberg; M Holley; R Jungwirth; P Mangold; T Röhnisch; S Schweighart; R Wilhelm
Journal:  Infection       Date:  1992 May-Jun       Impact factor: 3.553

4.  Cloning and nucleotide sequencing of the gene encoding the beta-lactamase from Citrobacter diversus.

Authors:  M Perilli; N Franceschini; B Segatore; G Amicosante; A Oratore; C Duez; B Joris; J M Frère
Journal:  FEMS Microbiol Lett       Date:  1991-09-15       Impact factor: 2.742

5.  A plasmid-mediated beta-lactamase conferring resistance to cefotaxime in a Salmonella typhimurium clone found in St Petersburg, Russia.

Authors:  M Gazouli; S V Sidorenko; E Tzelepi; N S Kozlova; D P Gladin; L S Tzouvelekis
Journal:  J Antimicrob Chemother       Date:  1998-01       Impact factor: 5.790

6.  A new plasmidic cefotaximase in a clinical isolate of Escherichia coli.

Authors:  A Bauernfeind; H Grimm; S Schweighart
Journal:  Infection       Date:  1990 Sep-Oct       Impact factor: 3.553

7.  Cefotaxime-hydrolysing activity of the beta-lactamase of Klebsiella oxytoca D488 could be related to a threonine residue at position 140.

Authors:  A Reynaud; J Péduzzi; M Barthélémy; R Labia
Journal:  FEMS Microbiol Lett       Date:  1991-06-15       Impact factor: 2.742

8.  Comparison of the sequences of class A beta-lactamases and of the secondary structure elements of penicillin-recognizing proteins.

Authors:  B Joris; P Ledent; O Dideberg; E Fonzé; J Lamotte-Brasseur; J A Kelly; J M Ghuysen; J M Frère
Journal:  Antimicrob Agents Chemother       Date:  1991-11       Impact factor: 5.191

9.  Chromosomally encoded cephalosporin-hydrolyzing beta-lactamase of Proteus vulgaris RO104 belongs to Ambler's class A.

Authors:  J Péduzzi; A Reynaud; P Baron; M Barthélémy; R Labia
Journal:  Biochim Biophys Acta       Date:  1994-07-20

10.  Chromosomal beta-lactamase of Klebsiella oxytoca, a new class A enzyme that hydrolyzes broad-spectrum beta-lactam antibiotics.

Authors:  Y Arakawa; M Ohta; N Kido; M Mori; H Ito; T Komatsu; Y Fujii; N Kato
Journal:  Antimicrob Agents Chemother       Date:  1989-01       Impact factor: 5.191
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  48 in total

1.  Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-10) isolated in Spain.

Authors:  A Oliver; J C Pérez-Díaz; T M Coque; F Baquero; R Cantón
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

2.  Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-9) from Escherichia coli in Spain.

Authors:  M Sabaté; R Tarragó; F Navarro; E Miró; C Vergés; J Barbé; G Prats
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

3.  Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

Authors:  L Poirel; I Le Thomas; T Naas; A Karim; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

4.  First isolation of a CTX-M-3-producing Enterobacter cloacae in France.

Authors:  F Doucet-Populaire; J C Ghnassia; R Bonnet; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

5.  Salmonella enterica serovar virchow with CTX-M-like beta-lactamase in Spain.

Authors:  E Simarro; F Navarro; J Ruiz; E Miró; J Gómez; B Mirelis
Journal:  J Clin Microbiol       Date:  2000-12       Impact factor: 5.948

6.  BetalasEN: microdilution panel for identifying beta-lactamases present in isolates of Enterobacteriaceae.

Authors:  Christine C Sanders; Anton F Ehrhardt; Ellen Smith Moland; Kenneth S Thomson; Barbara Zimmer; Darcie E Roe
Journal:  J Clin Microbiol       Date:  2002-01       Impact factor: 5.948

7.  Early dissemination of CTX-M-derived enzymes in South America.

Authors:  Marcela Radice; Pablo Power; Jose Di Conza; Gabriel Gutkind
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

8.  Countrywide spread of CTX-M-3 extended-spectrum beta-lactamase-producing microorganisms of the family Enterobacteriaceae in Poland.

Authors:  Anna Baraniak; Janusz Fiett; Agnieszka Sulikowska; Waleria Hryniewicz; Marek Gniadkowski
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

9.  Plasmidic extended-spectrum beta-lactamases in Vibrio cholerae O1 El Tor isolates in Argentina.

Authors:  Alejandro Petroni; Alejandra Corso; Roberto Melano; María Luisa Cacace; Ana María Bru; Alicia Rossi; Marcelo Galas
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

10.  Three cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among Enterobacteriaceae in the People's Republic of China.

Authors:  Aroonwadee Chanawong; Fatima Hannachi M'Zali; John Heritage; Jian-Hui Xiong; Peter Michael Hawkey
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191
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