Literature DB >> 9589062

Cystothiazoles A and B, new bithiazole-type antibiotics from the myxobacterium Cystobacter fuscus.

M Ojika1, Y Suzuki, A Tsukamoto, Y Sakagami, R Fudou, T Yoshimura, S Yamanaka.   

Abstract

New bithiazole-type antibiotics, cystothiazoles A (C20H26N2O4S2) and B (C20H26N2O5S2), have been isolated from a culture broth of the myxobacterium, Cystobacter fuscus. The gross structures of these compounds were elucidated by spectroscopic analysis, and their absolute stereochemistry was determined by chemical degradation of cystothiazole A. Cystothiazole A inhibits fungi and human tumor cells, whereas it is inactive against bacteria. The antifungal activity appears to result from the inhibition of submitochondrial NADH oxidation. Although these compounds are structurally related to the known antibiotic myxothiazol, cystothiazole A was more active against fungi and less cytotoxic than myxothiazol.

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Year:  1998        PMID： 9589062     DOI： 10.7164/antibiotics.51.275

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  PCR detection of type I polyketide synthase genes in myxobacteria.

Authors:  Hisayuki Komaki; Ryosuke Fudou; Takashi Iizuka; Daisuke Nakajima; Koei Okazaki; Daisuke Shibata; Makoto Ojika; Shigeaki Harayama
Journal:  Appl Environ Microbiol       Date:  2008-07-07       Impact factor: 4.792

2.  Catalytic Reactions and Energy Conservation in the Cytochrome bc1 and b6f Complexes of Energy-Transducing Membranes.

Authors:  Marcin Sarewicz; Sebastian Pintscher; Rafał Pietras; Arkadiusz Borek; Łukasz Bujnowicz; Guy Hanke; William A Cramer; Giovanni Finazzi; Artur Osyczka
Journal:  Chem Rev       Date:  2021-01-19       Impact factor: 60.622

Review 3.  Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.

Authors:  Patrick C Still; Tyler A Johnson; Christine M Theodore; Steven T Loveridge; Phillip Crews
Journal:  J Nat Prod       Date:  2014-02-26       Impact factor: 4.050

4.  New MCRs: the first 4-component reaction leading to 2,4-disubstituted thiazoles.

Authors:  Jürgen Kolb; Barbara Beck; Michael Almstetter; Stefan Heck; Eberhardt Herdtweck; Alexander Dömling
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

5.  Heterologous Production of the Marine Myxobacterial Antibiotic Haliangicin and Its Unnatural Analogues Generated by Engineering of the Biochemical Pathway.

Authors:  Yuwei Sun; Zhiyang Feng; Tomohiko Tomura; Akira Suzuki; Seishi Miyano; Takashi Tsuge; Hitoshi Mori; Joo-Won Suh; Takashi Iizuka; Ryosuke Fudou; Makoto Ojika
Journal:  Sci Rep       Date:  2016-02-26       Impact factor: 4.379

6.  Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases.

Authors:  Simona Distinto; Rita Meleddu; Francesco Ortuso; Filippo Cottiglia; Serenella Deplano; Lisa Sequeira; Claudia Melis; Benedetta Fois; Andrea Angeli; Clemente Capasso; Rossella Angius; Stefano Alcaro; Claudiu T Supuran; Elias Maccioni
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

7.  Acetylcholinesterase-inhibiting activity of pyrrole derivatives from a novel marine gliding bacterium, Rapidithrix thailandica.

Authors:  Yutthapong Sangnoi; Oraphan Sakulkeo; Supreeya Yuenyongsawad; Akkharawit Kanjana-opas; Kornkanok Ingkaninan; Anuchit Plubrukarn; Khanit Suwanborirux
Journal:  Mar Drugs       Date:  2008-10-13       Impact factor: 5.118
  7 in total

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