Literature DB >> 958231

Mutagenic mechanism of 5-bromodeoxyuridine in Chinese hamster cells.

P M Aebersold.   

Abstract

Resistance to 6-thioguanine was induced by 5-bromodeoxyuridine (BUdR) in synchronous Chinese hamster cells. The yield of mutant colonies was not proportional to the amount of BUdR incorporated into DNA; thus mutants were not due to mispairing of BUdR with guanine during replication. Few mutants were induced until BUdR concentrations exceeded that of the intracellular thymidine triphosphate pool and mutant yield was depressed by addition of thymidine to the medium. These data suggest that BUdR exerts an allosteric effect on the DNA synthesizing system which renders it more error prone.

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Year:  1976        PMID： 958231     DOI： 10.1016/0027-5107(76)90245-1

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  10 in total

1.  Differential cell cycle phase specificity for neoplastic transformation and mutation to ouabain resistance induced by N-methyl-N'-nitro-N-nitrosoguanidine in synchronized C3H10T 1/2 C18 cells.

Authors:  P J McCormick; J S Bertram
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

2.  Deoxyribonucleotide pools, base pairing, and sequence configuration affecting bromodeoxyuridine- and 2-aminopurine-induced mutagenesis.

Authors:  R L Hopkins; M F Goodman
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

3.  Bromodeoxyuridine mutagenesis in mammalian cells: mutagenesis is independent of the amount of bromouracil in DNA.

Authors:  E R Kaufman; R L Davidson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

4.  Base analogue mutagenesis in yeast and its modulation by pyrimidine deoxynucleotide pool imbalances: incorporation of bromodeoxyuridylate and iododeoxyuridylate.

Authors:  L S Ross; O Landman; J G Little
Journal:  Curr Genet       Date:  1987       Impact factor: 3.886

5.  Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity.

Authors:  L M Fox; J A Mekras; C B Bagwell; S B Greer
Journal:  Antimicrob Agents Chemother       Date:  1982-09       Impact factor: 5.191

6.  Bromodeoxyuridine-induced mutations in synchronous Chinese hamster cells: temporal induction of 6-thioguanine and ouabain resistance during DNA replication.

Authors:  H J Burki; P M Aebersold
Journal:  Genetics       Date:  1978-10       Impact factor: 4.562

7.  Reversion analysis of mutations induced by 5-bromodeoxyuridine mutagenesis in mammalian cells.

Authors:  E R Kaufman
Journal:  Mol Cell Biol       Date:  1985-11       Impact factor: 4.272

8.  Bromodeoxyuridine mutagenesis in mammalian cells is related to deoxyribonucleotide pool imbalance.

Authors:  C R Ashman; R L Davidson
Journal:  Mol Cell Biol       Date:  1981-03       Impact factor: 4.272

9.  Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools.

Authors:  G Weinberg; B Ullman; D W Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

10.  Replication of DNA containing 5-bromouracil can be mutagenic in Syrian hamster cells.

Authors:  E R Kaufman
Journal:  Mol Cell Biol       Date:  1984-11       Impact factor: 4.272
  10 in total

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