| Literature DB >> 9582120 |
L M Frenkel1, J I Mullins, G H Learn, L Manns-Arcuino, B L Herring, M L Kalish, R W Steketee, D M Thea, J E Nichols, S L Liu, A Harmache, X He, D Muthui, A Madan, L Hood, A T Haase, M Zupancic, K Staskus, S Wolinsky, P Krogstad, J Zhao, I Chen, R Koup, D Ho, B Korber, R J Apple, R W Coombs, S Pahwa, N J Roberts.
Abstract
Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.Entities:
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Year: 1998 PMID： 9582120 DOI： 10.1126/science.280.5366.1073
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728