Literature DB >> 24390641

Are infants unique in their ability to be "functionally cured" of HIV-1?

Nicole H Tobin1, Grace M Aldrovandi.   

Abstract

The recent report of an infant that appears to have achieved a "functional cure" of HIV-1 following receipt of antiretroviral therapy (ART) within 30 hours of birth raises many questions: was the child infected? Was this result due to unique features of this particular infant's immune system, the immune system of infants or the very early initiation of effective ART? In this manuscript, we discuss the pathogenesis of HIV-1 in infants, highlighting the unique features of infant immune development and how these may inform efforts to cure HIV infection. We will also compare the path to infant "cure" to cures in adults.

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Year:  2014        PMID： 24390641     DOI： 10.1007/s11904-013-0189-1

Source DB:  PubMed          Journal:  Curr HIV/AIDS Rep        ISSN： 1548-3568            Impact factor:   5.071


  87 in total

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2.  Understanding the timing of HIV transmission from mother to infant.

Authors:  A P Kourtis; M Bulterys; S R Nesheim; F K Lee
Journal:  JAMA       Date:  2001-02-14       Impact factor: 56.272

3.  Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

Authors:  Janet D Siliciano; Joleen Kajdas; Diana Finzi; Thomas C Quinn; Karen Chadwick; Joseph B Margolick; Colin Kovacs; Stephen J Gange; Robert F Siliciano
Journal:  Nat Med       Date:  2003-05-18       Impact factor: 53.440

4.  Proposed definitions for in utero versus intrapartum transmission of HIV-1.

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Journal:  N Engl J Med       Date:  1992-10-22       Impact factor: 91.245

5.  Paediatric reference values for the peripheral T cell compartment.

Authors:  E J H Schatorjé; E F A Gemen; G J A Driessen; J Leuvenink; R W N M van Hout; E de Vries
Journal:  Scand J Immunol       Date:  2012-04       Impact factor: 3.487

6.  Infection of cord blood monocyte-derived macrophages with human immunodeficiency virus type 1.

Authors:  W Z Ho; J Lioy; L Song; J R Cutilli; R A Polin; S D Douglas
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

7.  Natural killer T cells constitutively expressing the interleukin-2 receptor α chain early in life are primed to respond to lower antigenic stimulation.

Authors:  Mihoko Ladd; Ashish Sharma; Qing Huang; Adele Y Wang; Lixin Xu; Indira Genowati; Megan K Levings; Pascal M Lavoie
Journal:  Immunology       Date:  2010-10       Impact factor: 7.397

8.  A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators.

Authors:  M Lallemant; G Jourdain; S Le Coeur; S Kim; S Koetsawang; A M Comeau; W Phoolcharoen; M Essex; K McIntosh; V Vithayasai
Journal:  N Engl J Med       Date:  2000-10-05       Impact factor: 91.245

9.  HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

Authors:  Nicolas Chomont; Mohamed El-Far; Petronela Ancuta; Lydie Trautmann; Francesco A Procopio; Bader Yassine-Diab; Geneviève Boucher; Mohamed-Rachid Boulassel; Georges Ghattas; Jason M Brenchley; Timothy W Schacker; Brenna J Hill; Daniel C Douek; Jean-Pierre Routy; Elias K Haddad; Rafick-Pierre Sékaly
Journal:  Nat Med       Date:  2009-06-21       Impact factor: 53.440

10.  Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient.

Authors:  Steven A Yukl; Eli Boritz; Michael Busch; Christopher Bentsen; Tae-Wook Chun; Daniel Douek; Evelyn Eisele; Ashley Haase; Ya-Chi Ho; Gero Hütter; J Shawn Justement; Sheila Keating; Tzong-Hae Lee; Peilin Li; Danielle Murray; Sarah Palmer; Christopher Pilcher; Satish Pillai; Richard W Price; Meghan Rothenberger; Timothy Schacker; Janet Siliciano; Robert Siliciano; Elizabeth Sinclair; Matt Strain; Joseph Wong; Douglas Richman; Steven G Deeks
Journal:  PLoS Pathog       Date:  2013-05-09       Impact factor: 6.823
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  8 in total

1.  Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed.

Authors:  Louise Kuhn; Diana B Schramm; Stephanie Shiau; Renate Strehlau; Francoise Pinillos; Karl Technau; Ashraf Coovadia; Elaine J Abrams; Adrian Puren; Caroline T Tiemessen
Journal:  AIDS       Date:  2015-06-01       Impact factor: 4.177

Review 2.  The pharmacological treatment of acute HIV infections in neonates.

Authors:  Louise Kuhn; Stephanie Shiau
Journal:  Expert Rev Clin Pharmacol       Date:  2017-11-03       Impact factor: 5.045

3.  Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4.

Authors:  Guan-Han Li; Caroline Anderson; Laura Jaeger; Thao Do; Eugene O Major; Avindra Nath
Journal:  AIDS       Date:  2015-04-24       Impact factor: 4.177

Review 4.  Immune activation and paediatric HIV-1 disease outcome.

Authors:  Julia M Roider; Maximilian Muenchhoff; Philip J R Goulder
Journal:  Curr Opin HIV AIDS       Date:  2016-03       Impact factor: 4.283

5.  Recovery of effective HIV-specific CD4+ T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia.

Authors:  Emily Adland; Luisa Mori; Leana Laker; Anna Csala; Maximilian Muenchhoff; Alice Swordy; Masa Mori; Philippa Matthews; Gareth Tudor-Williams; Pieter Jooste; Philip Goulder
Journal:  AIDS       Date:  2018-07-17       Impact factor: 4.177

6.  Early antiretroviral treatment of infants to attain HIV remission.

Authors:  Louise Kuhn; Renate Strehlau; Stephanie Shiau; Faeezah Patel; Yanhan Shen; Karl-Günter Technau; Megan Burke; Gayle Sherman; Ashraf Coovadia; Grace M Aldrovandi; Rohan Hazra; Wei-Yann Tsai; Caroline T Tiemessen; Elaine J Abrams
Journal:  EClinicalMedicine       Date:  2020-01-07

7.  Early ART Results in Greater Immune Reconstitution Benefits in HIV-Infected Infants: Working with Data Missingness in a Longitudinal Dataset.

Authors:  Livio Azzoni; Russell Barbour; Emmanouil Papasavvas; Deborah K Glencross; Wendy S Stevens; Mark F Cotton; Avy Violari; Luis J Montaner
Journal:  PLoS One       Date:  2015-12-15       Impact factor: 3.240

8.  Age at antiretroviral therapy initiation and cell-associated HIV-1 DNA levels in HIV-1-infected children.

Authors:  Louise Kuhn; Maria Paximadis; Bianca Da Costa Dias; Shayne Loubser; Renate Strehlau; Faeezah Patel; Stephanie Shiau; Ashraf Coovadia; Elaine J Abrams; Caroline T Tiemessen
Journal:  PLoS One       Date:  2018-04-12       Impact factor: 3.240
  8 in total

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