Literature DB >> 9578985

The search for orally active medications through combinatorial chemistry.

R A Fecik1, K E Frank, E J Gentry, S R Menon, L A Mitscher, H Telikepalli.   

Abstract

The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.

Mesh：

Year:  1998        PMID： 9578985     DOI： 10.1002/(sici)1098-1128(199805)18:3<149::aid-med2>3.0.co;2-x

Source DB:  PubMed          Journal:  Med Res Rev        ISSN： 0198-6325            Impact factor:   12.944


  8 in total

Review 1.  Exploring privileged structures: the combinatorial synthesis of cyclic peptides.

Authors:  Douglas A Horton; Gregory T Bourne; Mark L Smythe
Journal:  J Comput Aided Mol Des       Date:  2002 May-Jun       Impact factor: 3.686

Review 2.  Exploring privileged structures: the combinatorial synthesis of cyclic peptides.

Authors:  Douglas A Horton; Gregory T Bourne; Mark L Smythe
Journal:  Mol Divers       Date:  2002       Impact factor: 2.943

3.  Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions.

Authors:  Tran T Tran; Christina Kulis; Steven M Long; Darryn Bryant; Peter Adams; Mark L Smythe
Journal:  J Comput Aided Mol Des       Date:  2010-09-23       Impact factor: 3.686

4.  Do benzodiazepines mimic reverse-turn structures?

Authors:  Masayuki Hata; Garland R Marshall
Journal:  J Comput Aided Mol Des       Date:  2006-09-14       Impact factor: 3.686

Review 5.  Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors.

Authors:  Christian W Gruber; Markus Muttenthaler; Michael Freissmuth
Journal:  Curr Pharm Des       Date:  2010       Impact factor: 3.116

6.  Predicting human oral bioavailability of a compound: development of a novel quantitative structure-bioavailability relationship.

Authors:  C W Andrews; L Bennett; L X Yu
Journal:  Pharm Res       Date:  2000-06       Impact factor: 4.200

7.  A strategy for primary high throughput cytotoxicity screening in pharmaceutical toxicology.

Authors:  P J Bugelski; U Atif; S Molton; I Toeg; P G Lord; D G Morgan
Journal:  Pharm Res       Date:  2000-10       Impact factor: 4.200

8.  Computational approaches for modeling human intestinal absorption and permeability.

Authors:  Govindan Subramanian; Douglas B Kitchen
Journal:  J Mol Model       Date:  2006-04-01       Impact factor: 1.810
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.