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Literature DB >> 9573127

Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules.

C R Zimmermann¹, S M Johnson, G W Martens, A G White, B L Zimmer, D Pappagianis.

Abstract

The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with C. immitis.

Entities: Chemical Disease Species

Mesh：

Substances：
Fungal Vaccines

Year: 1998 PMID： 9573127 PMCID： PMC108201 DOI： 10.1128/IAI.66.5.2342-2345.1998

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

25 in total

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25 in total

1. A parasitic phase-specific adhesin of Coccidioides immitis contributes to the virulence of this respiratory Fungal pathogen.

Authors: Chiung-Yu Hung; Jieh-Juen Yu; Kalpathi R Seshan; Utz Reichard; Garry T Cole
Journal: Infect Immun Date: 2002-07 Impact factor: 3.441

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Authors: Neil M Ampel
Journal: Mycopathologia Date: 2003 Impact factor: 2.574

3. An archived lot of coccidioidin induces specific coccidioidal delayed-type hypersensitivity and correlates with in vitro assays of coccidioidal cellular immune response.

Authors: Neil M Ampel; Richard F Hector; Christina P Lindan; George W Rutherford
Journal: Mycopathologia Date: 2006-02 Impact factor: 2.574

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Journal: Infect Immun Date: 1999-02 Impact factor: 3.441

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Authors: Garry T Cole; Brady J Hurtgen; Chiung-Yu Hung
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Authors: Lance Nesbit; Suzanne M Johnson; Demosthenes Pappagianis; Neil M Ampel
Journal: Infect Immun Date: 2009-11-09 Impact factor: 3.441

8. Vaccine-induced cellular immune responses differ from innate responses in susceptible and resistant strains of mice infected with Coccidioides posadasii.

Authors: Lisa F Shubitz; Sharon M Dial; Robert Perrill; Rachael Casement; John N Galgiani
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Authors: Brady J Hurtgen; Natalia Castro-Lopez; Maria Del Pilar Jiménez-Alzate; Garry T Cole; Chiung-Yu Hung
Journal: Vaccine Date: 2016-09-09 Impact factor: 3.641

10. In vitro whole-blood analysis of cellular immunity in patients with active coccidioidomycosis by using the antigen preparation T27K.

Authors: Neil M Ampel; Larissa A Kramer; Lijin Li; Deborah S Carroll; Kathleen M Kerekes; Suzanne M Johnson; Demosthenes Pappagianis
Journal: Clin Diagn Lab Immunol Date: 2002-09