Literature DB >> 6822433

Coccidioides immitis vaccine: potential of an alkali-soluble, water-soluble cell wall antigen.

G Lecara, R A Cox, R B Simpson.   

Abstract

C-ASWS-M, the alkali-soluble, water-soluble cell wall antigen of Coccidioides immitis mycelia, was evaluated for its vaccine potential in mice. Vaccination with 0.5-, 1.5-, or 3-mg doses of C-ASWS-M in complete Freund adjuvant provided a significant level of protection against intraperitoneal challenge with 1,500 arthroconidia (P < 0.0001 with each dose). Vaccination with 1 mg of C-ASWS-M protected mice against intranasal challenge with 50 (P < 0.05) and 500 (P < 0.01) arthroconidia, but not against intranasal challenge with 1,500 arthroconidia (P > 0.05).

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Year:  1983        PMID： 6822433      PMCID： PMC347967          DOI： 10.1128/iai.39.1.473-475.1983

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  9 in total

1.  IMMUNIZATION OF MICE TO COCCIDIOIDES IMMITIS: DOSE, REGIMEN AND SPHERULATION STAGE OF KILLED SPHERULE VACCINES.

Authors:  H B LEVINE; Y C KONG; C SMITH
Journal:  J Immunol       Date:  1965-01       Impact factor: 5.422

2.  Immunogenic properties of nondisrupted and disrupted spherules of Coccidioides immitis in mice.

Authors:  Y C KONG; H B LEVINE; C E SMITH
Journal:  Sabouraudia       Date:  1963-02

3.  Immunogenicity of spherule-endospore vaccines of Coccidioides immitis for mice.

Authors:  H B LEVINE; J M COBB; C E SMITH
Journal:  J Immunol       Date:  1961-08       Impact factor: 5.422

4.  Immunity to coccidioi-domycosis induced in mice by purified spherule, arthrospore, and mycelial vaccines.

Authors:  H B LEVINE; J M COBB; C E SMITH
Journal:  Trans N Y Acad Sci       Date:  1960-04

5.  In vitro lymphocyte responses of coccidioidin skin test-positive and -negative persons to coccidioidin, spherulin, and a coccidioides cell wall antigen.

Authors:  R A Cox; E Brummer; G Lecara
Journal:  Infect Immun       Date:  1977-03       Impact factor: 3.441

Review 6.  Experimentally induced immunity in the mycoses.

Authors:  Y C Kong; H B Levine
Journal:  Bacteriol Rev       Date:  1967-03

7.  Enhancement of immune responses in mice by a booster injection of Coccidioides spherules.

Authors:  Y M Kong; D C Savage; H B Levine
Journal:  J Immunol       Date:  1965-12       Impact factor: 5.422

8.  Immunization of mice against coccidioidomycosis with a subcellular vaccine.

Authors:  D Pappagianis; R Hector; H B Levine; M S Collins
Journal:  Infect Immun       Date:  1979-07       Impact factor: 3.441

9.  Delayed-type hypersensitivity responses to a cell wall fraction of the mycelial phase of Coccidioides immitis.

Authors:  E R Ward; R A Cox; J A Schmitt; M Huppert; S H Sun
Journal:  Infect Immun       Date:  1975-11       Impact factor: 3.441
  9 in total
  19 in total

1.  Coadministration of interleukin 12 expression vector with antigen 2 cDNA enhances induction of protective immunity against Coccidioides immitis.

Authors:  C Jiang; D M Magee; R A Cox
Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

Review 2.  An insight into the antifungal pipeline: selected new molecules and beyond.

Authors:  Luis Ostrosky-Zeichner; Arturo Casadevall; John N Galgiani; Frank C Odds; John H Rex
Journal:  Nat Rev Drug Discov       Date:  2010-08-20       Impact factor: 84.694

3.  A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice.

Authors:  Eric J Tarcha; Venkatesha Basrur; Chiung-Yu Hung; Malcolm J Gardner; Garry T Cole
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

4.  Production of a murine monoclonal antibody that recognizes an epitope specific to Coccidioides immitis antigen 2.

Authors:  R A Cox; M J Dolan; D M Magee; J N Galgiani
Journal:  Infect Immun       Date:  1993-05       Impact factor: 3.441

5.  Evaluation of the proline-rich antigen of Coccidioides immitis as a vaccine candidate in mice.

Authors:  T N Kirkland; F Finley; K I Orsborn; J N Galgiani
Journal:  Infect Immun       Date:  1998-08       Impact factor: 3.441

6.  Genetic vaccination against Coccidioides immitis: comparison of vaccine efficacy of recombinant antigen 2 and antigen 2 cDNA.

Authors:  C Jiang; D M Magee; T N Quitugua; R A Cox
Journal:  Infect Immun       Date:  1999-02       Impact factor: 3.441

7.  Molecular cloning and characterization of Coccidioides immitis antigen 2 cDNA.

Authors:  Y Zhu; C Yang; D M Magee; R A Cox
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

8.  Induction and expression of cell-mediated immune responses in inbred mice infected with Coccidioides immitis.

Authors:  R A Cox; W Kennell; L Boncyk; J W Murphy
Journal:  Infect Immun       Date:  1988-01       Impact factor: 3.441

9.  Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules.

Authors:  C R Zimmermann; S M Johnson; G W Martens; A G White; B L Zimmer; D Pappagianis
Journal:  Infect Immun       Date:  1998-05       Impact factor: 3.441

Review 10.  Coccidioidomycosis: host response and vaccine development.

Authors:  Rebecca A Cox; D Mitchell Magee
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132
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