Cellular responses to DNA damage.

The exposure of cells to DNA damage inducers triggers a wide range of cellular responses including an alteration in gene expression, a delay in cell-cycle progression and the stimulation of DNA repair. In multicellular organisms, DNA damage can also activate programmed cell death. Recently, several signaling pathways that link DNA damage to gene expression and to the cell-cycle checkpoints have been identified. These pathways establish a framework for future studies of DNA damage responses.