Literature DB >> 956044

A new semisynthetic 7alpha-methoxycephalosporin, CS-1170: 7beta-((cyanomethyl)thio)acetamido)-7alpha-methoxy-3-((1-methyl-1H-tetrazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid.

H Nakao, H Yanagisawa, B Shimizu, M Kaneko, M Nagano.   

Abstract

The synthesis and antimicrobial activity of a new semisynthetic 7alpha-methoxycephalosporin,7beta [[(cyanomethyl)thiol]acetamidol]-7alpha-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]-methyl]-3-cephem-4-carboxylic acid (CS-1170), are described. This compound shows interesting antibacterial activity when compared to cefoxitin and cephalothin.

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Year:  1976        PMID： 956044     DOI： 10.7164/antibiotics.29.554

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  16 in total

1.  Antimicrobial activity of cefmetazole (CS-1170) and recommendations for susceptibility testing by disk diffusion, dilution, and anaerobic methods.

Authors:  R N Jones; A L Barry; P C Fuchs; C Thornsberry
Journal:  J Clin Microbiol       Date:  1986-12       Impact factor: 5.948

2.  Pharmacokinetics and dose proportionality of cefmetazole in healthy young and elderly volunteers.

Authors:  M T Borin; G R Peters; T C Smith
Journal:  Antimicrob Agents Chemother       Date:  1990-10       Impact factor: 5.191

3.  Disposition of cefmetazole in healthy volunteers and patients with impaired renal function.

Authors:  C E Halstenson; D R Guay; J A Opsahl; C A Hirata; L S Olanoff; E Novak; H Ko; K S Cathcart; G R Matzke
Journal:  Antimicrob Agents Chemother       Date:  1990-04       Impact factor: 5.191

4.  Serum concentrations of antibiotics during severe invasive surgery such as esophagectomy for esophageal cancer.

Authors:  Tetsuhiro Owaki; Hiroshi Okumura; Yasuto Uchikado; Ken Sasaki; Masataka Matsumoto; Itaru Omoto; Tetsuro Setoyama; Yoshiaki Kita; Toshihide Sakurai; Daisuke Matsushita; Sumiya Ishigami; Shinichi Ueno; Shoji Natsugoe
Journal:  Int Surg       Date:  2013 Jan-Mar

5.  Pharmacokinetics of cefmetazole administered intramuscularly and intravenously to healthy adults.

Authors:  J Rodriguez-Barbero; E L Mariño; A Dominguez-Gil
Journal:  Antimicrob Agents Chemother       Date:  1985-10       Impact factor: 5.191

6.  Activity of beta-lactamase produced by Bacteroides fragilis against newly introduced cephalosporins.

Authors:  K Sato; M Inoue; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1980-04       Impact factor: 5.191

7.  Penicillin-insensitive incorporation of D-amino acids into cell wall peptidoglycan influences the amount of bound lipoprotein in Escherichia coli.

Authors:  T Tsuruoka; A Tamura; A Miyata; T Takei; K Iwamatsu; S Inouye; M Matsuhashi
Journal:  J Bacteriol       Date:  1984-12       Impact factor: 3.490

8.  Pharmacokinetics of single-dose cefmetazole following intramuscular administration of cefmetazole sodium to healthy male volunteers.

Authors:  H Ko; E Novak; G R Peters; W M Bothwell; J D Hosley; S K Closson; W J Adams
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

9.  Antibacterial activities of SM-1652 compared with those of other broad-spectrum cephalosporins.

Authors:  M Kato; M Inoue; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1982-11       Impact factor: 5.191

10.  Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination.

Authors:  H Ko; K S Cathcart; D L Griffith; G R Peters; W J Adams
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191
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