Literature DB >> 956034

A new broad spectrum aminoglycoside antibiotic, G-52, produced by Micromonospora zionensis.

J A Marquez, G H Wagman, R T Testa, J A Waitz, M J Weinstein.   

Abstract

G-52 is a new broad spectrum aminoglycoside produced by a species of the genus Micromonospora, Micromonospora zionensis. It has been differentiated from other known related antibiotics by a variety of chemical and biological methods. Its in vitro and in vivo spectrum of activity appears to be quite similar to that of verdamicin and gentamicin but is differentiated from them by its increased activity against 6'-N-acetylating strains.

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Year:  1976        PMID: 956034     DOI: 10.7164/antibiotics.29.483

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  3 in total

1.  Biotransformation of sisomicin to gentamicin C2b.

Authors:  B K Lee; J V Bailey; R G Condon; J A Marquez; G H Wagman; M J Weinstein
Journal:  Antimicrob Agents Chemother       Date:  1977-09       Impact factor: 5.191

Review 2.  The genus Micromonospora as a model microorganism for bioactive natural product discovery.

Authors:  Mohamed S Hifnawy; Mohamed M Fouda; Ahmed M Sayed; Rabab Mohammed; Hossam M Hassan; Sameh F AbouZid; Mostafa E Rateb; Alexander Keller; Martina Adamek; Nadine Ziemert; Usama Ramadan Abdelmohsen
Journal:  RSC Adv       Date:  2020-06-08       Impact factor: 4.036

3.  The bifunctional enzyme, GenB4, catalyzes the last step of gentamicin 3',4'-di-deoxygenation via reduction and transamination activities.

Authors:  Xiaotang Chen; Hui Zhang; Shaotong Zhou; Mingjun Bi; Shizhou Qi; Huiyuan Gao; Xianpu Ni; Huanzhang Xia
Journal:  Microb Cell Fact       Date:  2020-03-10       Impact factor: 5.328

  3 in total

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